Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania
The anti-COVID-19 vaccines, developed for use during the pandemic period, must be evaluated for effectiveness in order to coordinate the vaccination program. Therefore, this study aimed to measure the anti-COVID-19 vaccine effectiveness (VE) and duration of protection against symptomatic forms of in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/3/521 |
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| author | Maria I. Brumboiu Edina Iuga Andreea Ivanciuc Sergiu Mutaffof Alice S. Tudosa Cristina Gherasimovici Irina Iaru |
| author_facet | Maria I. Brumboiu Edina Iuga Andreea Ivanciuc Sergiu Mutaffof Alice S. Tudosa Cristina Gherasimovici Irina Iaru |
| author_sort | Maria I. Brumboiu |
| collection | DOAJ |
| description | The anti-COVID-19 vaccines, developed for use during the pandemic period, must be evaluated for effectiveness in order to coordinate the vaccination program. Therefore, this study aimed to measure the anti-COVID-19 vaccine effectiveness (VE) and duration of protection against symptomatic forms of infection among healthcare personnel who were professionally exposed to the SARS-CoV-2 virus. A prospective cohort study, which was conducted in a university hospital between January 2021 and April 2022, compared immunologically naïve and previously infected personnel who were vaccinated, revaccinated, or unvaccinated. The VE was measured based on survival rates constructed with the actuarial method, using 30 day intervals. Among the 783 subjects that were included in the study, those that were vaccinated showed a decrease in VE from 90.98% (95% confidence intervals (CI): 74.87–96.77) in the first 30 days to 69.95% (95% CI: 40.29–84.87) at 60 days after vaccination. The VE for revaccinated personnel was 93.27% (95% CI: 77.53–97.99) at 60 days and 86.54% (95% CI: 75.59–92.58) at 90 days after revaccination. For previously infected personnel, protection against reinfection was 94.03% (95% CI: 79.41–98.27) at 420 days and 82.08% (95% CI: 53.93–93.03) at 450 days after revaccination. The highest VE for preventing the symptomatic forms of COVID-19 was observed in the revaccinated, but only for a 3-month duration. Better protection against reinfection was provided by revaccination after passing through infection. |
| first_indexed | 2024-03-11T05:48:23Z |
| format | Article |
| id | doaj.art-a2ba6c414a5249b397edfb2af01db695 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T05:48:23Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a2ba6c414a5249b397edfb2af01db6952023-11-17T14:17:18ZengMDPI AGVaccines2076-393X2023-02-0111352110.3390/vaccines11030521Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, RomaniaMaria I. Brumboiu0Edina Iuga1Andreea Ivanciuc2Sergiu Mutaffof3Alice S. Tudosa4Cristina Gherasimovici5Irina Iaru6Epidemiology Department, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaEpidemiology Department, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaEpidemiology Department, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaEpidemiology Department, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaHospital Epidemiology Department, University Infectious Diseases Hospital, 400348 Cluj-Napoca, RomaniaHospital Epidemiology Department, University Infectious Diseases Hospital, 400348 Cluj-Napoca, RomaniaCluj Unit, French-Speaking International Clinical Epidemiology Network, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaThe anti-COVID-19 vaccines, developed for use during the pandemic period, must be evaluated for effectiveness in order to coordinate the vaccination program. Therefore, this study aimed to measure the anti-COVID-19 vaccine effectiveness (VE) and duration of protection against symptomatic forms of infection among healthcare personnel who were professionally exposed to the SARS-CoV-2 virus. A prospective cohort study, which was conducted in a university hospital between January 2021 and April 2022, compared immunologically naïve and previously infected personnel who were vaccinated, revaccinated, or unvaccinated. The VE was measured based on survival rates constructed with the actuarial method, using 30 day intervals. Among the 783 subjects that were included in the study, those that were vaccinated showed a decrease in VE from 90.98% (95% confidence intervals (CI): 74.87–96.77) in the first 30 days to 69.95% (95% CI: 40.29–84.87) at 60 days after vaccination. The VE for revaccinated personnel was 93.27% (95% CI: 77.53–97.99) at 60 days and 86.54% (95% CI: 75.59–92.58) at 90 days after revaccination. For previously infected personnel, protection against reinfection was 94.03% (95% CI: 79.41–98.27) at 420 days and 82.08% (95% CI: 53.93–93.03) at 450 days after revaccination. The highest VE for preventing the symptomatic forms of COVID-19 was observed in the revaccinated, but only for a 3-month duration. Better protection against reinfection was provided by revaccination after passing through infection.https://www.mdpi.com/2076-393X/11/3/521vaccine effectivenessCOVID-19healthcare personnelprotection duration |
| spellingShingle | Maria I. Brumboiu Edina Iuga Andreea Ivanciuc Sergiu Mutaffof Alice S. Tudosa Cristina Gherasimovici Irina Iaru Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania Vaccines vaccine effectiveness COVID-19 healthcare personnel protection duration |
| title | Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania |
| title_full | Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania |
| title_fullStr | Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania |
| title_full_unstemmed | Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania |
| title_short | Effectiveness and Protection Duration of Anti-COVID-19 Vaccinations among Healthcare Personnel in Cluj-Napoca, Romania |
| title_sort | effectiveness and protection duration of anti covid 19 vaccinations among healthcare personnel in cluj napoca romania |
| topic | vaccine effectiveness COVID-19 healthcare personnel protection duration |
| url | https://www.mdpi.com/2076-393X/11/3/521 |
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