Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma
<p><strong>Purpose</strong>: to study the antioxidant activity of carbonic anhydrase inhibitors and timolol fixed combinations and to compare it with other fixed combinations.<br /><strong>Methods</strong>: Antioxidant activity (AOA) of dorzolamide/timolol (Cosopt...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2014-07-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | http://www.ophthalmojournal.com/index.php/opht/article/view/175 |
| _version_ | 1819280919947640832 |
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| author | N. I. Kurysheva O. A. Azizova A. P. Piryazev |
| author_facet | N. I. Kurysheva O. A. Azizova A. P. Piryazev |
| author_sort | N. I. Kurysheva |
| collection | DOAJ |
| description | <p><strong>Purpose</strong>: to study the antioxidant activity of carbonic anhydrase inhibitors and timolol fixed combinations and to compare it with other fixed combinations.<br /><strong>Methods</strong>: Antioxidant activity (AOA) of dorzolamide/timolol (Cosopt), dorzolamide/timolol (Dorzopt Plus), latanoprost/timolol, brimonidine/timolol, travoprost/timolol and bimatoprost/timolol fixed combinations was measured in vitro using the model of oxida- tive hemolysis.<br /><strong>Results</strong>: Dorzolamide/timolol (Cosopt) AOA was higher than that of other fixed combinations and increased with the quantity of the drugs added to the model system: 40%, 52% and 75% in 30 μl, 60 μl and 90 μl respectively.<br /><strong>Conclusion</strong>: these findings suggest that dorzolamide/timolol fixed combination has potential advantages over the other fixed combinations due to its high antioxidant activity and might be used as the neuroptotective agent for glaucoma treatment.</p> |
| first_indexed | 2024-12-24T00:51:27Z |
| format | Article |
| id | doaj.art-a2bb3e09384c4259806feb31f59022b3 |
| institution | Directory Open Access Journal |
| issn | 1816-5095 |
| language | Russian |
| last_indexed | 2024-12-24T00:51:27Z |
| publishDate | 2014-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj.art-a2bb3e09384c4259806feb31f59022b32022-12-21T17:23:35ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952014-07-01944751175Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucomaN. I. Kurysheva0O. A. Azizova1A. P. Piryazev2Центр офтальмологии ФМБА РоссииНИИ физико-химической медицины ФМБА России, МоскваНИИ физико-химической медицины ФМБА России, Москва<p><strong>Purpose</strong>: to study the antioxidant activity of carbonic anhydrase inhibitors and timolol fixed combinations and to compare it with other fixed combinations.<br /><strong>Methods</strong>: Antioxidant activity (AOA) of dorzolamide/timolol (Cosopt), dorzolamide/timolol (Dorzopt Plus), latanoprost/timolol, brimonidine/timolol, travoprost/timolol and bimatoprost/timolol fixed combinations was measured in vitro using the model of oxida- tive hemolysis.<br /><strong>Results</strong>: Dorzolamide/timolol (Cosopt) AOA was higher than that of other fixed combinations and increased with the quantity of the drugs added to the model system: 40%, 52% and 75% in 30 μl, 60 μl and 90 μl respectively.<br /><strong>Conclusion</strong>: these findings suggest that dorzolamide/timolol fixed combination has potential advantages over the other fixed combinations due to its high antioxidant activity and might be used as the neuroptotective agent for glaucoma treatment.</p>http://www.ophthalmojournal.com/index.php/opht/article/view/175оxidative stressglaucomafixed combinationsdorzolamidetimolol |
| spellingShingle | N. I. Kurysheva O. A. Azizova A. P. Piryazev Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma Oftalʹmologiâ оxidative stress glaucoma fixed combinations dorzolamide timolol |
| title | Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma |
| title_full | Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma |
| title_fullStr | Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma |
| title_full_unstemmed | Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma |
| title_short | Antioxidant activity of dorzolamide/timolol fixed combination in neuroprotective therapy in glaucoma |
| title_sort | antioxidant activity of dorzolamide timolol fixed combination in neuroprotective therapy in glaucoma |
| topic | оxidative stress glaucoma fixed combinations dorzolamide timolol |
| url | http://www.ophthalmojournal.com/index.php/opht/article/view/175 |
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