Exogenous Flupirtine as Potential Treatment for CLN3 Disease

Exogenous Flupirtine as Potential Treatment for CLN3 Disease

CLN3 disease is a fatal neurodegenerative disorder affecting children. Hallmarks include brain atrophy, accelerated neuronal apoptosis, and ceramide elevation. Treatment regimens are supportive, highlighting the importance of novel, disease-modifying drugs. Flupirtine and its new allyl carbamate der...

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Bibliographic Details
Main Authors: Katia Maalouf, Joelle Makoukji, Sara Saab, Nadine J. Makhoul, Angelica V. Carmona, Nihar Kinarivala, Noël Ghanem, Paul C. Trippier, Rose-Mary Boustany
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
sphingolipids
neurodegeneration
ceramide
CLN3 disease
<i>Cln3<sup>Δex7/8</sup></i> mice
flupirtine
Online Access:https://www.mdpi.com/2073-4409/9/8/1872

Internet

https://www.mdpi.com/2073-4409/9/8/1872

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