Isolated hemolytic anemia: an unusual manifestation of occult malignancy
Hemolysis is an uncommon and usually late complication of malignancy, and very rarely the presenting feature. Cancer-associated hemolysis may be immune-mediated, or may result from thrombotic microangiopathy accompanied by thrombocytopenia. We describe an unusual case of isolated hemolysis in the se...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/5159 |
| _version_ | 1828046285800734720 |
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| author | Matthew J. Butler Ming Yin Fahd Quddus |
| author_facet | Matthew J. Butler Ming Yin Fahd Quddus |
| author_sort | Matthew J. Butler |
| collection | DOAJ |
| description | Hemolysis is an uncommon and usually late complication of malignancy, and very rarely the presenting feature. Cancer-associated hemolysis may be immune-mediated, or may result from thrombotic microangiopathy accompanied by thrombocytopenia. We describe an unusual case of isolated hemolysis in the setting of occult metastatic breast cancer. The patient initially presented with symptomatic anemia, with evidence of hemolysis but with negative direct antiglobulin testing and a normal platelet count. Subsequent investigation discovered metastatic adenocarcinoma of the breast involving bone marrow. Hemolysis worsened despite initial treatment with cytotoxic chemotherapy and a trial of corticosteroids, but later resolved with aromatase inhibitor therapy. |
| first_indexed | 2024-04-10T18:24:47Z |
| format | Article |
| id | doaj.art-a2bfefc2eb284cb4b1e5a6d36cb5374b |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:24:47Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-a2bfefc2eb284cb4b1e5a6d36cb5374b2023-02-02T06:24:36ZengMDPI AGHematology Reports2038-83222038-83302014-02-016110.4081/hr.2014.51592722Isolated hemolytic anemia: an unusual manifestation of occult malignancyMatthew J. Butler0Ming Yin1Fahd Quddus2Department of Internal Medicine, Geisinger Medical Center, Danville, PADepartment of Internal Medicine, Geisinger Medical Center, Danville, PADepartment of Hematology and Oncology, Geisinger Medical Center, Danville, PAHemolysis is an uncommon and usually late complication of malignancy, and very rarely the presenting feature. Cancer-associated hemolysis may be immune-mediated, or may result from thrombotic microangiopathy accompanied by thrombocytopenia. We describe an unusual case of isolated hemolysis in the setting of occult metastatic breast cancer. The patient initially presented with symptomatic anemia, with evidence of hemolysis but with negative direct antiglobulin testing and a normal platelet count. Subsequent investigation discovered metastatic adenocarcinoma of the breast involving bone marrow. Hemolysis worsened despite initial treatment with cytotoxic chemotherapy and a trial of corticosteroids, but later resolved with aromatase inhibitor therapy.http://www.pagepress.org/journals/index.php/hr/article/view/5159hemolysis, hemolytic anemia, malignancy, cancer |
| spellingShingle | Matthew J. Butler Ming Yin Fahd Quddus Isolated hemolytic anemia: an unusual manifestation of occult malignancy Hematology Reports hemolysis, hemolytic anemia, malignancy, cancer |
| title | Isolated hemolytic anemia: an unusual manifestation of occult malignancy |
| title_full | Isolated hemolytic anemia: an unusual manifestation of occult malignancy |
| title_fullStr | Isolated hemolytic anemia: an unusual manifestation of occult malignancy |
| title_full_unstemmed | Isolated hemolytic anemia: an unusual manifestation of occult malignancy |
| title_short | Isolated hemolytic anemia: an unusual manifestation of occult malignancy |
| title_sort | isolated hemolytic anemia an unusual manifestation of occult malignancy |
| topic | hemolysis, hemolytic anemia, malignancy, cancer |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/5159 |
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