Neuroinflammation Involved in Diabetes-Related Pain and Itch
Diabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society. Diabetic neuropathy is the most common chronic complication of DM, resulting in neuropathic pain...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.921612/full |
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| author | Xiao-Xia Fang Xiao-Xia Fang Heng Wang Hao-Lin Song Juan Wang Zhi-Jun Zhang |
| author_facet | Xiao-Xia Fang Xiao-Xia Fang Heng Wang Hao-Lin Song Juan Wang Zhi-Jun Zhang |
| author_sort | Xiao-Xia Fang |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society. Diabetic neuropathy is the most common chronic complication of DM, resulting in neuropathic pain and chronic itch. The precise mechanisms of diabetic neuropathy have not been fully clarified, hindering the exploration of novel therapies for diabetic neuropathy and its terrible symptoms such as diabetic pain and itch. Accumulating evidence suggests that neuroinflammation plays a critical role in the pathophysiologic process of neuropathic pain and chronic itch. Indeed, researchers have currently made significant progress in knowing the role of glial cells and the pro-inflammatory mediators produced from glial cells in the modulation of chronic pain and itch signal processing. Here, we provide an overview of the current understanding of neuroinflammation in contributing to the sensitization of the peripheral nervous system (PNS) and central nervous system (CNS). In addition, we also summarize the inflammation mechanisms that contribute to the pathogenesis of diabetic itch, including activation of glial cells, oxidative stress, and pro-inflammatory factors. Targeting excessive neuroinflammation may provide potential and effective therapies for the treatment of chronic neuropathic pain and itch in DM. |
| first_indexed | 2024-12-12T16:29:48Z |
| format | Article |
| id | doaj.art-a2c1f87f4bcb49a0aa06dbcb281aff1e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T16:29:48Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a2c1f87f4bcb49a0aa06dbcb281aff1e2022-12-22T00:18:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-06-011310.3389/fphar.2022.921612921612Neuroinflammation Involved in Diabetes-Related Pain and ItchXiao-Xia Fang0Xiao-Xia Fang1Heng Wang2Hao-Lin Song3Juan Wang4Zhi-Jun Zhang5Department of Human Anatomy, School of Medicine, Nantong University, Nantong, ChinaDepartment of Medical Functional Laboratory, School of Medicine, Nantong University, Nantong, ChinaDepartment of Human Anatomy, School of Medicine, Nantong University, Nantong, ChinaDepartment of Human Anatomy, School of Medicine, Nantong University, Nantong, ChinaDepartment of Human Anatomy, School of Medicine, Nantong University, Nantong, ChinaDepartment of Human Anatomy, School of Medicine, Nantong University, Nantong, ChinaDiabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society. Diabetic neuropathy is the most common chronic complication of DM, resulting in neuropathic pain and chronic itch. The precise mechanisms of diabetic neuropathy have not been fully clarified, hindering the exploration of novel therapies for diabetic neuropathy and its terrible symptoms such as diabetic pain and itch. Accumulating evidence suggests that neuroinflammation plays a critical role in the pathophysiologic process of neuropathic pain and chronic itch. Indeed, researchers have currently made significant progress in knowing the role of glial cells and the pro-inflammatory mediators produced from glial cells in the modulation of chronic pain and itch signal processing. Here, we provide an overview of the current understanding of neuroinflammation in contributing to the sensitization of the peripheral nervous system (PNS) and central nervous system (CNS). In addition, we also summarize the inflammation mechanisms that contribute to the pathogenesis of diabetic itch, including activation of glial cells, oxidative stress, and pro-inflammatory factors. Targeting excessive neuroinflammation may provide potential and effective therapies for the treatment of chronic neuropathic pain and itch in DM.https://www.frontiersin.org/articles/10.3389/fphar.2022.921612/fullneuroinflammationdiabetes mellitusdiabetic paindiabetic itchsensitization |
| spellingShingle | Xiao-Xia Fang Xiao-Xia Fang Heng Wang Hao-Lin Song Juan Wang Zhi-Jun Zhang Neuroinflammation Involved in Diabetes-Related Pain and Itch Frontiers in Pharmacology neuroinflammation diabetes mellitus diabetic pain diabetic itch sensitization |
| title | Neuroinflammation Involved in Diabetes-Related Pain and Itch |
| title_full | Neuroinflammation Involved in Diabetes-Related Pain and Itch |
| title_fullStr | Neuroinflammation Involved in Diabetes-Related Pain and Itch |
| title_full_unstemmed | Neuroinflammation Involved in Diabetes-Related Pain and Itch |
| title_short | Neuroinflammation Involved in Diabetes-Related Pain and Itch |
| title_sort | neuroinflammation involved in diabetes related pain and itch |
| topic | neuroinflammation diabetes mellitus diabetic pain diabetic itch sensitization |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.921612/full |
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