RESEARCH OF INFLUENCE OF POLYMORPHISM Μ-OPIOID RECEPTOR GENE ON THE TOTAL INTRAVENOUS ANAESTHESIA
Purpose: To study the influence of polymorphism µ-opioid receptor for the total intravenous anesthesia.Materials and methods: The study included 100 patients, which were performed by various gynecological operations withthe entry into the abdominal cavity. Intraoperative in all patients evaluated th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2014-03-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/220 |
| Summary: | Purpose: To study the influence of polymorphism µ-opioid receptor for the total intravenous anesthesia.Materials and methods: The study included 100 patients, which were performed by various gynecological operations withthe entry into the abdominal cavity. Intraoperative in all patients evaluated the change bispectral index, blood pressure, oxygensaturation. Analyzed the frequency of the polymorphism of gene mu-opioid receptor OPRM1 (A118G).Results: We found that the carriers of polymorphic genotype of the study of the gene was observed increased consumptionof narcotic analgesics during the operation, later performed extubation, often recorded postoperative complications (nausea andvomiting) and there was a higher score on the visual-analogue scale in the early postoperative period.Summary: The carriers of polymorphic genotype of µ-opioid receptor А118G, as heterozygous and homozygous are need ofhigher doses of narcotic analgesics during surgery and the more careful observation in the early postoperative period because ofthe possible complications. |
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| ISSN: | 2219-8075 2618-7876 |