ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW
Periodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodon...
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| Format: | Article |
| Language: | English |
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Khyber Medical University
2020-12-01
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| Series: | Khyber Medical University Journal |
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| Online Access: | https://www.kmuj.kmu.edu.pk/article/view/19808 |
| _version_ | 1797807326195875840 |
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| author | Hamda Shazam Fouzia Shaikh Muhammad Mansoor Majeed Sadia Khan Saba Khan |
| author_facet | Hamda Shazam Fouzia Shaikh Muhammad Mansoor Majeed Sadia Khan Saba Khan |
| author_sort | Hamda Shazam |
| collection | DOAJ |
| description | Periodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodontal disease varies and reported a higher prevalence in Asian countries. The conventional diagnostic techniques used for periodontitis are inherently limited. Periodontitis immunopathogenesis studies and mediator analyzes in saliva allowed the identification of a number of disease-specific molecular biomarkers. In this review article, diagnostic role of various salivary biomarkers in periodontitis has been discussed. Original articles, systematic and narrative reviews related to relevant study, published since 2009-2019 were included in the literature search through PubMed, Google Scholar, Web of Science and Scopus. Convenient assessments of these salivary biomarkers with analytical chair facilities will yield more accurate diagnostic results which will further aid in early detection and better clinical management of periodontitis patients. |
| first_indexed | 2024-03-13T06:20:53Z |
| format | Article |
| id | doaj.art-a2c569935949428c81cd2417e5efed22 |
| institution | Directory Open Access Journal |
| issn | 2305-2643 2305-2651 |
| language | English |
| last_indexed | 2024-03-13T06:20:53Z |
| publishDate | 2020-12-01 |
| publisher | Khyber Medical University |
| record_format | Article |
| series | Khyber Medical University Journal |
| spelling | doaj.art-a2c569935949428c81cd2417e5efed222023-06-09T19:10:57ZengKhyber Medical UniversityKhyber Medical University Journal2305-26432305-26512020-12-011243263010.35845/kmuj.2020.198081209ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEWHamda Shazam0Fouzia Shaikh1Muhammad Mansoor Majeed2Sadia Khan3Saba Khan4Department of Oral Pathology, Ziauddin University, Karachi, PakistanDepartment of Pathology, Ziauddin University, Karachi, PakistanDepartment of Oral Pathology, Ziauddin University, Karachi, Pakistan currently working in Department of Oral Biology, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Biostatistics, The University of Lahore, Lahore, PakistanDepartment of Oral Pathology, Ziauddin University, Karachi, PakistanPeriodontitis, a chronic inflammatory disease of oral cavity, caused by the complex interactions between host immune system and sub-gingival microbiota leading to chronic gingival inflammation, loss of periodontal ligament attachment, dental impairment, and finally tooth loss. Prevalence of periodontal disease varies and reported a higher prevalence in Asian countries. The conventional diagnostic techniques used for periodontitis are inherently limited. Periodontitis immunopathogenesis studies and mediator analyzes in saliva allowed the identification of a number of disease-specific molecular biomarkers. In this review article, diagnostic role of various salivary biomarkers in periodontitis has been discussed. Original articles, systematic and narrative reviews related to relevant study, published since 2009-2019 were included in the literature search through PubMed, Google Scholar, Web of Science and Scopus. Convenient assessments of these salivary biomarkers with analytical chair facilities will yield more accurate diagnostic results which will further aid in early detection and better clinical management of periodontitis patients.https://www.kmuj.kmu.edu.pk/article/view/19808salivabiomarkerperiodontitisdiagnosisgingivitisosteocalcincytokinesmatrix metalloproteinasesgrowth factors |
| spellingShingle | Hamda Shazam Fouzia Shaikh Muhammad Mansoor Majeed Sadia Khan Saba Khan ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW Khyber Medical University Journal saliva biomarker periodontitis diagnosis gingivitis osteocalcin cytokines matrix metalloproteinases growth factors |
| title | ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW |
| title_full | ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW |
| title_fullStr | ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW |
| title_full_unstemmed | ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW |
| title_short | ROLE OF SALIVARY BIOMARKERS IN DIAGNOSIS OF PERIODONTITIS – A LITERATURE REVIEW |
| title_sort | role of salivary biomarkers in diagnosis of periodontitis a literature review |
| topic | saliva biomarker periodontitis diagnosis gingivitis osteocalcin cytokines matrix metalloproteinases growth factors |
| url | https://www.kmuj.kmu.edu.pk/article/view/19808 |
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