Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies
Tumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation of TNFα in the context of an exercise intervention among older adults with cancer is understudied. In this exploratory analysis, we used data from a single-arm mobile health (mHealth) exercise inter...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
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| Series: | Experimental Gerontology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556524000068 |
| _version_ | 1797295823351971840 |
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| author | Kah Poh Loh Ying Wang Chandrika Sanapala Nikesha Gilmore Colleen Netherby-Winslow Jason H. Mendler Jane Liesveld Eric Huselton AnnaLynn M. Williams Heidi D. Klepin Marielle Jensen-Battaglia Karen Mustian Paula Vertino Martha Susiarjo Michelle C. Janelsins |
| author_facet | Kah Poh Loh Ying Wang Chandrika Sanapala Nikesha Gilmore Colleen Netherby-Winslow Jason H. Mendler Jane Liesveld Eric Huselton AnnaLynn M. Williams Heidi D. Klepin Marielle Jensen-Battaglia Karen Mustian Paula Vertino Martha Susiarjo Michelle C. Janelsins |
| author_sort | Kah Poh Loh |
| collection | DOAJ |
| description | Tumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation of TNFα in the context of an exercise intervention among older adults with cancer is understudied. In this exploratory analysis, we used data from a single-arm mobile health (mHealth) exercise intervention among older adults with myeloid malignancies to 1) assess changes in TNFα promoter methylation, TNFα mRNA expression, serum TNFα and other related-cytokine levels after intervention; and 2) assess correlations between blood markers and exercise levels. Twenty patients were included. From baseline to post-intervention, there was no statistical changes in TNFα promoter methylation status at seven CpG sites, TNFα mRNA expression, and serum TNFα levels. Effect sizes, however, were moderate to large for several CpG sites (−120, −147, −162, and −164; Cohen's d = 0.44–0.75). Median serum TNFα sR1 levels increased (83.63, IQR 130.58, p = 0.06; Cohen's d = 0.18) but not the other cytokines. Increases in average daily steps were correlated with increases in TNFα promoter methylation at CpG sites −147 (r = 0.48; p = 0.06) and −164 (r = 0.51; p = 0.04). Resistance training minutes were negatively correlated with TNFα promoter methylation at CpG site −120 (r = −0.62; p = 0.02). All effect sizes were moderate to large. In conclusion, after a mHealth exercise intervention, we demonstrated changes with moderate to large effect sizes in several CpG sites in the TNFα promoter region. Exercise levels were correlated with increases in TNFα promoter methylation. Larger exercise trials are needed to better evaluate TNFα regulation to inform interventions to augment TNFα regulation in order to improve outcomes in older adults with cancer. |
| first_indexed | 2024-03-07T21:54:31Z |
| format | Article |
| id | doaj.art-a2c5f7669d0d4a2a84a1f0ed403061bd |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-07T21:54:31Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-a2c5f7669d0d4a2a84a1f0ed403061bd2024-02-25T04:34:43ZengElsevierExperimental Gerontology1873-68152024-03-01187112364Exercise and inflammatory cytokine regulation among older adults with myeloid malignanciesKah Poh Loh0Ying Wang1Chandrika Sanapala2Nikesha Gilmore3Colleen Netherby-Winslow4Jason H. Mendler5Jane Liesveld6Eric Huselton7AnnaLynn M. Williams8Heidi D. Klepin9Marielle Jensen-Battaglia10Karen Mustian11Paula Vertino12Martha Susiarjo13Michelle C. Janelsins14James P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA; Corresponding author at: Division of Hematology/Oncology, Department of Medicine, James P. Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA.Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USABurrell College of Osteopathic Medicine, Las Cruces, NM, USADivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USADivision of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USAWake Forest Baptist Comprehensive Cancer Center, Medical Center Blvd, Winston-Salem, NC, USADepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USADepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USAJames P. Wilmot Cancer Institute, Rochester, NY, USA; Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY, USATumor necrosis factor (TNF)α is a major regulator of inflammation. However, the epigenetic regulation of TNFα in the context of an exercise intervention among older adults with cancer is understudied. In this exploratory analysis, we used data from a single-arm mobile health (mHealth) exercise intervention among older adults with myeloid malignancies to 1) assess changes in TNFα promoter methylation, TNFα mRNA expression, serum TNFα and other related-cytokine levels after intervention; and 2) assess correlations between blood markers and exercise levels. Twenty patients were included. From baseline to post-intervention, there was no statistical changes in TNFα promoter methylation status at seven CpG sites, TNFα mRNA expression, and serum TNFα levels. Effect sizes, however, were moderate to large for several CpG sites (−120, −147, −162, and −164; Cohen's d = 0.44–0.75). Median serum TNFα sR1 levels increased (83.63, IQR 130.58, p = 0.06; Cohen's d = 0.18) but not the other cytokines. Increases in average daily steps were correlated with increases in TNFα promoter methylation at CpG sites −147 (r = 0.48; p = 0.06) and −164 (r = 0.51; p = 0.04). Resistance training minutes were negatively correlated with TNFα promoter methylation at CpG site −120 (r = −0.62; p = 0.02). All effect sizes were moderate to large. In conclusion, after a mHealth exercise intervention, we demonstrated changes with moderate to large effect sizes in several CpG sites in the TNFα promoter region. Exercise levels were correlated with increases in TNFα promoter methylation. Larger exercise trials are needed to better evaluate TNFα regulation to inform interventions to augment TNFα regulation in order to improve outcomes in older adults with cancer.http://www.sciencedirect.com/science/article/pii/S0531556524000068Myeloid malignanciesMobile healthExerciseInflammationDNA methylationCytokines |
| spellingShingle | Kah Poh Loh Ying Wang Chandrika Sanapala Nikesha Gilmore Colleen Netherby-Winslow Jason H. Mendler Jane Liesveld Eric Huselton AnnaLynn M. Williams Heidi D. Klepin Marielle Jensen-Battaglia Karen Mustian Paula Vertino Martha Susiarjo Michelle C. Janelsins Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies Experimental Gerontology Myeloid malignancies Mobile health Exercise Inflammation DNA methylation Cytokines |
| title | Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| title_full | Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| title_fullStr | Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| title_full_unstemmed | Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| title_short | Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| title_sort | exercise and inflammatory cytokine regulation among older adults with myeloid malignancies |
| topic | Myeloid malignancies Mobile health Exercise Inflammation DNA methylation Cytokines |
| url | http://www.sciencedirect.com/science/article/pii/S0531556524000068 |
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