SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons
<b>Purpose:</b> To determine the impact of booster COVID-19 vaccination on SARS-CoV-2 symptoms. <b>Background</b>: The Omicron surge of infections provided an opportunity to evaluate symptoms in relation to booster receipt. <b>Methods:</b> At a US medical college,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/12/3/327 |
| _version_ | 1797239115461165056 |
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| author | Marisa A. Montecalvo Paul Visintainer Elizabeth Drugge Katherine Kowalski Rosemarie Raffa Donna McKenna Christine Moronta Gary P. Wormser |
| author_facet | Marisa A. Montecalvo Paul Visintainer Elizabeth Drugge Katherine Kowalski Rosemarie Raffa Donna McKenna Christine Moronta Gary P. Wormser |
| author_sort | Marisa A. Montecalvo |
| collection | DOAJ |
| description | <b>Purpose:</b> To determine the impact of booster COVID-19 vaccination on SARS-CoV-2 symptoms. <b>Background</b>: The Omicron surge of infections provided an opportunity to evaluate symptoms in relation to booster receipt. <b>Methods:</b> At a US medical college, the number, type, and duration of symptoms were evaluated for 476 students or employees, factoring in days between last vaccination and SARS-CoV-2 diagnosis. <b>Results:</b> Compared with vaccinated non-boosted individuals, boosted individuals reported a significantly higher frequency of nasal congestion (57.9% vs. 44.4%, <i>p</i> = 0.018) and nasal congestion and/or sore throat (77.2% vs. 62.0%, <i>p</i> = 0.003); in contrast, the frequency of body/muscle aches was significantly less among boosted individuals (22.1% vs. 32.4%, <i>p</i> = 0.038). With each one week increase in time since booster receipt, the probability of fever increased significantly by 4.4% (OR 1.044, 95% CI 1.01, 1.07, <i>p</i> = 0.001), and the probability of cough increased significantly by 4.8% (OR 1.048, 95% CI 1.01, 10.8, <i>p</i>= 0.010). <b>Conclusions:</b> Within a medical college population, during the first 7 months of the Omicron surge of infections, compared with vaccinated non-boosted individuals, boosted individuals significantly more often reported the following: nasal congestion as well as nasal congestion and/or sore throat. In contrast, body/muscle aches were reported significantly less often. The rates of fever and cough each significantly increased as time since booster dose receipt increased. These data suggest that having had a booster vaccination, as well the timing of receiving it, impacts the clinical manifestations of breakthrough SARS-CoV-2 infections. Additional studies are needed to precisely define SARS-CoV-2 symptoms in relation to booster vaccinations. |
| first_indexed | 2024-04-24T17:46:24Z |
| format | Article |
| id | doaj.art-a2c60ac818ca428d98db36f6b6d330f9 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-24T17:46:24Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-a2c60ac818ca428d98db36f6b6d330f92024-03-27T14:07:09ZengMDPI AGVaccines2076-393X2024-03-0112332710.3390/vaccines12030327SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted PersonsMarisa A. Montecalvo0Paul Visintainer1Elizabeth Drugge2Katherine Kowalski3Rosemarie Raffa4Donna McKenna5Christine Moronta6Gary P. Wormser7Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USADepartment of Epidemiology and Biostatistics, University of Massachusetts Chan Medical School–Baystate, Springfield, MA 01119, USADepartment of Public Health, Division of Epidemiology, New York Medical College, Valhalla, NY 10595, USADepartment of Health Services, New York Medical College, Valhalla, NY 10595, USADepartment of Health Services, New York Medical College, Valhalla, NY 10595, USADepartment of Health Services, New York Medical College, Valhalla, NY 10595, USADepartment of Health Services, New York Medical College, Valhalla, NY 10595, USADepartment of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, NY 10595, USA<b>Purpose:</b> To determine the impact of booster COVID-19 vaccination on SARS-CoV-2 symptoms. <b>Background</b>: The Omicron surge of infections provided an opportunity to evaluate symptoms in relation to booster receipt. <b>Methods:</b> At a US medical college, the number, type, and duration of symptoms were evaluated for 476 students or employees, factoring in days between last vaccination and SARS-CoV-2 diagnosis. <b>Results:</b> Compared with vaccinated non-boosted individuals, boosted individuals reported a significantly higher frequency of nasal congestion (57.9% vs. 44.4%, <i>p</i> = 0.018) and nasal congestion and/or sore throat (77.2% vs. 62.0%, <i>p</i> = 0.003); in contrast, the frequency of body/muscle aches was significantly less among boosted individuals (22.1% vs. 32.4%, <i>p</i> = 0.038). With each one week increase in time since booster receipt, the probability of fever increased significantly by 4.4% (OR 1.044, 95% CI 1.01, 1.07, <i>p</i> = 0.001), and the probability of cough increased significantly by 4.8% (OR 1.048, 95% CI 1.01, 10.8, <i>p</i>= 0.010). <b>Conclusions:</b> Within a medical college population, during the first 7 months of the Omicron surge of infections, compared with vaccinated non-boosted individuals, boosted individuals significantly more often reported the following: nasal congestion as well as nasal congestion and/or sore throat. In contrast, body/muscle aches were reported significantly less often. The rates of fever and cough each significantly increased as time since booster dose receipt increased. These data suggest that having had a booster vaccination, as well the timing of receiving it, impacts the clinical manifestations of breakthrough SARS-CoV-2 infections. Additional studies are needed to precisely define SARS-CoV-2 symptoms in relation to booster vaccinations.https://www.mdpi.com/2076-393X/12/3/327SARS-CoV-2OmicronsymptomsCOVID-19 vaccinationboosters |
| spellingShingle | Marisa A. Montecalvo Paul Visintainer Elizabeth Drugge Katherine Kowalski Rosemarie Raffa Donna McKenna Christine Moronta Gary P. Wormser SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons Vaccines SARS-CoV-2 Omicron symptoms COVID-19 vaccination boosters |
| title | SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons |
| title_full | SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons |
| title_fullStr | SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons |
| title_full_unstemmed | SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons |
| title_short | SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons |
| title_sort | sars cov 2 symptoms during the omicron surge differ between boosted and vaccinated non boosted persons |
| topic | SARS-CoV-2 Omicron symptoms COVID-19 vaccination boosters |
| url | https://www.mdpi.com/2076-393X/12/3/327 |
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