Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs
Non-traumatic acute bilateral compartment syndrome is a rare condition that may lead to limb ischemia. We describe a case of this syndrome occurring after a five-kilometer walk in a young woman receiving chronic treatment with lurasidone, leading to a bilateral foot-drop and rhabdomyolysis of the an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023022545 |
| _version_ | 1827957365822980096 |
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| author | L. Bosco T. Russo Y.M. Falzone C. Butera A. Del Prete R. Mellone U. Del Carro M. Filippi S.C. Previtali |
| author_facet | L. Bosco T. Russo Y.M. Falzone C. Butera A. Del Prete R. Mellone U. Del Carro M. Filippi S.C. Previtali |
| author_sort | L. Bosco |
| collection | DOAJ |
| description | Non-traumatic acute bilateral compartment syndrome is a rare condition that may lead to limb ischemia. We describe a case of this syndrome occurring after a five-kilometer walk in a young woman receiving chronic treatment with lurasidone, leading to a bilateral foot-drop and rhabdomyolysis of the anterolateral compartment of both legs. Due to her late presentation in the emergency department, we opted for a conservative approach, closely monitoring her renal function. We noticed a subsequent clinical and biochemical improvement over the following days, with the patient returning to her daily routine in a matter of weeks, despite a persisting bilateral foot drop. Since atypical antipsychotics are known to be associated with rhabdomyolysis, while possibly exerting a toxic effect on mitochondria, we hypothesize that a mild aerobic physical exertion might have triggered the event, in the context of an iatrogenic muscle susceptibility to oxidative distress. |
| first_indexed | 2024-04-09T15:18:32Z |
| format | Article |
| id | doaj.art-a2c836db6acd4add9e4051cf3248d9b3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:18:32Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a2c836db6acd4add9e4051cf3248d9b32023-04-29T14:54:34ZengElsevierHeliyon2405-84402023-04-0194e15047Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legsL. Bosco0T. Russo1Y.M. Falzone2C. Butera3A. Del Prete4R. Mellone5U. Del Carro6M. Filippi7S.C. Previtali8Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neuromuscular Repair Unit, INSPE and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurology Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurology Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyDepartment of Radiology and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, ItalyDepartment of Radiology and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyNeurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neuromuscular Repair Unit, INSPE and Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Corresponding author. Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.Non-traumatic acute bilateral compartment syndrome is a rare condition that may lead to limb ischemia. We describe a case of this syndrome occurring after a five-kilometer walk in a young woman receiving chronic treatment with lurasidone, leading to a bilateral foot-drop and rhabdomyolysis of the anterolateral compartment of both legs. Due to her late presentation in the emergency department, we opted for a conservative approach, closely monitoring her renal function. We noticed a subsequent clinical and biochemical improvement over the following days, with the patient returning to her daily routine in a matter of weeks, despite a persisting bilateral foot drop. Since atypical antipsychotics are known to be associated with rhabdomyolysis, while possibly exerting a toxic effect on mitochondria, we hypothesize that a mild aerobic physical exertion might have triggered the event, in the context of an iatrogenic muscle susceptibility to oxidative distress.http://www.sciencedirect.com/science/article/pii/S2405844023022545Foot-dropWalkingRhabdomyolysisAtypical antipsychotics |
| spellingShingle | L. Bosco T. Russo Y.M. Falzone C. Butera A. Del Prete R. Mellone U. Del Carro M. Filippi S.C. Previtali Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs Heliyon Foot-drop Walking Rhabdomyolysis Atypical antipsychotics |
| title | Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs |
| title_full | Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs |
| title_fullStr | Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs |
| title_full_unstemmed | Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs |
| title_short | Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs |
| title_sort | going for a stroll on lurasidone considerations on an atypical case of acute compartment syndrome of both legs |
| topic | Foot-drop Walking Rhabdomyolysis Atypical antipsychotics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023022545 |
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