1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
BackgroundThe identification of a marker for hypoglycemia could help patients achieve strict glucose control with a lower risk of hypoglycemia. 1,5-Anhydro-D-glucitol (1,5-AG) reflects postprandial hyperglycemia in patients with well-controlled diabetes, which contributes to glycemic variability. Be...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2016-06-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-284.pdf |
| _version_ | 1818756683489345536 |
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| author | Min Kyeong Kim Hye Seung Jung Soo Heon Kwak Young Min Cho Kyong Soo Park Seong Yeon Kim |
| author_facet | Min Kyeong Kim Hye Seung Jung Soo Heon Kwak Young Min Cho Kyong Soo Park Seong Yeon Kim |
| author_sort | Min Kyeong Kim |
| collection | DOAJ |
| description | BackgroundThe identification of a marker for hypoglycemia could help patients achieve strict glucose control with a lower risk of hypoglycemia. 1,5-Anhydro-D-glucitol (1,5-AG) reflects postprandial hyperglycemia in patients with well-controlled diabetes, which contributes to glycemic variability. Because glycemic variability is related to hypoglycemia, we aimed to evaluate the value of 1,5-AG as a marker of hypoglycemia.MethodsWe enrolled 18 adults with type 2 diabetes mellitus (T2DM) receiving insulin therapy and assessed the occurrence of hypoglycemia within a 3-month period. We measured 1,5-AG level, performed a survey to score the severity of hypoglycemia, and applied a continuous glucose monitoring system (CGMS).Results1,5-AG was significantly lower in the high hypoglycemia-score group compared to the low-score group. Additionally, the duration of insulin treatment was significantly longer in the high-score group. Subsequent analyses were adjusted by the duration of insulin treatment and mean blood glucose, which was closely associated with both 1,5-AG level and hypoglycemia risk. In adjusted correlation analyses, 1,5-AG was negatively correlated with hypoglycemia score, area under the curve at 80 mg/dL, and low blood glucose index during CGMS (P=0.068, P=0.033, and P=0.060, respectively).Conclusion1,5-AG level was negatively associated with hypoglycemia score determined by recall and with documented hypoglycemia after adjusting for mean glucose and duration of insulin treatment. As a result, this level could be a marker of the risk of hypoglycemia in patients with well-controlled T2DM receiving insulin therapy. |
| first_indexed | 2024-12-18T05:58:56Z |
| format | Article |
| id | doaj.art-a2c91c1dcdb84941856260c48c6b8a40 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-18T05:58:56Z |
| publishDate | 2016-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-a2c91c1dcdb84941856260c48c6b8a402022-12-21T21:18:44ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782016-06-0131228429110.3803/EnM.2016.31.2.284202201,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin TherapyMin Kyeong KimHye Seung JungSoo Heon KwakYoung Min ChoKyong Soo ParkSeong Yeon KimBackgroundThe identification of a marker for hypoglycemia could help patients achieve strict glucose control with a lower risk of hypoglycemia. 1,5-Anhydro-D-glucitol (1,5-AG) reflects postprandial hyperglycemia in patients with well-controlled diabetes, which contributes to glycemic variability. Because glycemic variability is related to hypoglycemia, we aimed to evaluate the value of 1,5-AG as a marker of hypoglycemia.MethodsWe enrolled 18 adults with type 2 diabetes mellitus (T2DM) receiving insulin therapy and assessed the occurrence of hypoglycemia within a 3-month period. We measured 1,5-AG level, performed a survey to score the severity of hypoglycemia, and applied a continuous glucose monitoring system (CGMS).Results1,5-AG was significantly lower in the high hypoglycemia-score group compared to the low-score group. Additionally, the duration of insulin treatment was significantly longer in the high-score group. Subsequent analyses were adjusted by the duration of insulin treatment and mean blood glucose, which was closely associated with both 1,5-AG level and hypoglycemia risk. In adjusted correlation analyses, 1,5-AG was negatively correlated with hypoglycemia score, area under the curve at 80 mg/dL, and low blood glucose index during CGMS (P=0.068, P=0.033, and P=0.060, respectively).Conclusion1,5-AG level was negatively associated with hypoglycemia score determined by recall and with documented hypoglycemia after adjusting for mean glucose and duration of insulin treatment. As a result, this level could be a marker of the risk of hypoglycemia in patients with well-controlled T2DM receiving insulin therapy.http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-284.pdfHypoglycemia1,5-AnhydroglucitolDiabetes mellitus, Type 2Glycemic variabilityContinuous glucose monitoring system |
| spellingShingle | Min Kyeong Kim Hye Seung Jung Soo Heon Kwak Young Min Cho Kyong Soo Park Seong Yeon Kim 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy Endocrinology and Metabolism Hypoglycemia 1,5-Anhydroglucitol Diabetes mellitus, Type 2 Glycemic variability Continuous glucose monitoring system |
| title | 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy |
| title_full | 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy |
| title_fullStr | 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy |
| title_full_unstemmed | 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy |
| title_short | 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy |
| title_sort | 1 5 anhydro d glucitol could reflect hypoglycemia risk in patients with type 2 diabetes receiving insulin therapy |
| topic | Hypoglycemia 1,5-Anhydroglucitol Diabetes mellitus, Type 2 Glycemic variability Continuous glucose monitoring system |
| url | http://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-31-284.pdf |
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