Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma
Introduction. Paraganglioma is a rare neuroendocrine neoplasm that may arise from the extra-adrenal autonomic paraganglia. Urinary bladder paraganglioma is typically presented as repeated episodes of palpitations, headache or blood pressure rise immediately after micturition. Management of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500060D.pdf |
| Summary: | Introduction. Paraganglioma is a rare neuroendocrine neoplasm that may arise
from the extra-adrenal autonomic paraganglia. Urinary bladder paraganglioma
is typically presented as repeated episodes of palpitations, headache or
blood pressure rise immediately after micturition. Management of these tumors
includes radical surgical treatment with preoperative antihypertensive
preparation, and a life-long follow-up. Case report. We presented a middle-
age female patient with functional urinary bladder paraganglioma, with a
3-year history of repeated episodes of abdominal pain, dysuria and hematuria.
After obtaining more precise anamnestic data, the patient reported occasional
simultaneous presence of mild adrenergic symptoms, that did not cause any
particular attention at first. Morphological and biohumoral examinations
suggested paraganglioma of the urinary bladder. Open partial cystectomy was
performed, detecting a submucosal mass, while immunohistochemical analysis
confirmed the presence of chromaffin tissue. Clinical manifestations,
diagnostic approach, management and histopathological findings of urinary
bladder paraganglioma are discussed. Conclusion. Since the prognosis with
localized paraganglioma is good, we underlined the importance of a
well-timed, accurate and detailed medical history in all the patients with
even mild, inexplicable micturition-provoked adrenergic symptomatology. |
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| ISSN: | 0042-8450 2406-0720 |