Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma
Introduction. Paraganglioma is a rare neuroendocrine neoplasm that may arise from the extra-adrenal autonomic paraganglia. Urinary bladder paraganglioma is typically presented as repeated episodes of palpitations, headache or blood pressure rise immediately after micturition. Management of...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500060D.pdf |
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| author | Dragović Tamara Marinković Dejan Kuzmić-Janković Snežana Prelević Rade Milović Novak Kovačević Božidar Hajduković Zoran |
| author_facet | Dragović Tamara Marinković Dejan Kuzmić-Janković Snežana Prelević Rade Milović Novak Kovačević Božidar Hajduković Zoran |
| author_sort | Dragović Tamara |
| collection | DOAJ |
| description | Introduction. Paraganglioma is a rare neuroendocrine neoplasm that may arise
from the extra-adrenal autonomic paraganglia. Urinary bladder paraganglioma
is typically presented as repeated episodes of palpitations, headache or
blood pressure rise immediately after micturition. Management of these tumors
includes radical surgical treatment with preoperative antihypertensive
preparation, and a life-long follow-up. Case report. We presented a middle-
age female patient with functional urinary bladder paraganglioma, with a
3-year history of repeated episodes of abdominal pain, dysuria and hematuria.
After obtaining more precise anamnestic data, the patient reported occasional
simultaneous presence of mild adrenergic symptoms, that did not cause any
particular attention at first. Morphological and biohumoral examinations
suggested paraganglioma of the urinary bladder. Open partial cystectomy was
performed, detecting a submucosal mass, while immunohistochemical analysis
confirmed the presence of chromaffin tissue. Clinical manifestations,
diagnostic approach, management and histopathological findings of urinary
bladder paraganglioma are discussed. Conclusion. Since the prognosis with
localized paraganglioma is good, we underlined the importance of a
well-timed, accurate and detailed medical history in all the patients with
even mild, inexplicable micturition-provoked adrenergic symptomatology. |
| first_indexed | 2024-12-21T13:24:59Z |
| format | Article |
| id | doaj.art-a2c9fbeefaf64ce295f0fdaf04f687e2 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-21T13:24:59Z |
| publishDate | 2015-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-a2c9fbeefaf64ce295f0fdaf04f687e22022-12-21T19:02:30ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202015-01-0172983183610.2298/VSP140409060D0042-84501500060DUnrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paragangliomaDragović Tamara0Marinković Dejan1Kuzmić-Janković Snežana2Prelević Rade3Milović Novak4Kovačević Božidar5Hajduković Zoran6Military Medical Academy, Clinic for Endocrinology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeMilitary Medical Academy, Clinic for Endocrinology, BelgradeMilitary Medical Academy, Clinic for Endocrinology, BelgradeMilitary Medical Academy, Clinic for Urology, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Clinic for Urology, BelgradeMilitary Medical Academy, Institute of Pathology, BelgradeMilitary Medical Academy, Clinic for Endocrinology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeIntroduction. Paraganglioma is a rare neuroendocrine neoplasm that may arise from the extra-adrenal autonomic paraganglia. Urinary bladder paraganglioma is typically presented as repeated episodes of palpitations, headache or blood pressure rise immediately after micturition. Management of these tumors includes radical surgical treatment with preoperative antihypertensive preparation, and a life-long follow-up. Case report. We presented a middle- age female patient with functional urinary bladder paraganglioma, with a 3-year history of repeated episodes of abdominal pain, dysuria and hematuria. After obtaining more precise anamnestic data, the patient reported occasional simultaneous presence of mild adrenergic symptoms, that did not cause any particular attention at first. Morphological and biohumoral examinations suggested paraganglioma of the urinary bladder. Open partial cystectomy was performed, detecting a submucosal mass, while immunohistochemical analysis confirmed the presence of chromaffin tissue. Clinical manifestations, diagnostic approach, management and histopathological findings of urinary bladder paraganglioma are discussed. Conclusion. Since the prognosis with localized paraganglioma is good, we underlined the importance of a well-timed, accurate and detailed medical history in all the patients with even mild, inexplicable micturition-provoked adrenergic symptomatology.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500060D.pdfurinary bladder neoplasmsparagangliomadiagnosisurologic surgical procedureshistological techniques |
| spellingShingle | Dragović Tamara Marinković Dejan Kuzmić-Janković Snežana Prelević Rade Milović Novak Kovačević Božidar Hajduković Zoran Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma Vojnosanitetski Pregled urinary bladder neoplasms paraganglioma diagnosis urologic surgical procedures histological techniques |
| title | Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| title_full | Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| title_fullStr | Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| title_full_unstemmed | Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| title_short | Unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| title_sort | unrecognised adrenergic symptoms and the delayed diagnosis of urinary bladder paraganglioma |
| topic | urinary bladder neoplasms paraganglioma diagnosis urologic surgical procedures histological techniques |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500060D.pdf |
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