A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients
Abstract Background Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | Tropical Medicine and Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41182-020-00284-x |
| _version_ | 1818722743203397632 |
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| author | Saber Soltani Armin Zakeri Alireza Tabibzadeh Milad Zandi Elham Ershadi Sara Akhavan Rezayat Sanaz Khaseb Amir mohammad Zakeri Mohammadvala Ashtar Nakhaei Shervin Afzali Abbas Farahani |
| author_facet | Saber Soltani Armin Zakeri Alireza Tabibzadeh Milad Zandi Elham Ershadi Sara Akhavan Rezayat Sanaz Khaseb Amir mohammad Zakeri Mohammadvala Ashtar Nakhaei Shervin Afzali Abbas Farahani |
| author_sort | Saber Soltani |
| collection | DOAJ |
| description | Abstract Background Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. We summarize current knowledge about the prevalence rates of the parvovirus B19 infection in sickle cell anemia and thalassemia patients. Methods Several online databases were searched including, Scopus, EMBASE, Web of Science, Google Scholar, and PubMed, which were performed amidst 2009–2019 by using distinct keywords: “Thalassemia,” “Parvovirus,” “Anemia,” “Sickle cell anemia,” “parvoviridae,” “parvoviridae infection,” and “parvovirus B19.” Results Search results indicated 4 and 7 studies for the prevalence of the parvovirus B19 in β-thalassemia and SCD, respectively. Among the β-thalassemia patients, the B19V seroprevalence for IgG and IgM were ranged from 18.2–81% and 14.5–41.1%, respectively; meanwhile, B19V DNA positively results was 4–15.3%. Moreover, in the SCD group, the extent of B19V IgG was varied from 37.6 to 65.9% and that of IgM was in a range of 2.9–30%, and the DNA detection rate was 4–54%. Conclusion B19V seroprevalence changes in several conditions including, different epidemiological features, socio-economic status, and overpopulation. Age can expand the incidence of anti-B19V IgG/IgM in SCD and beta-thalassemia patients. Reinfection and diverse genotypes are relevant factors in the seroprevalence of B19v. The patients’ immunological-hematological station and higher abundance of transfusions can affect the B19V seroprevalence in SCD and beta-thalassemia group. Further investigations in this field could be suggested to better understand the virus distribution in this susceptible population of patients. |
| first_indexed | 2024-12-17T20:59:28Z |
| format | Article |
| id | doaj.art-a2ca1100476b4b2396b614c2db2fe666 |
| institution | Directory Open Access Journal |
| issn | 1349-4147 |
| language | English |
| last_indexed | 2024-12-17T20:59:28Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj.art-a2ca1100476b4b2396b614c2db2fe6662022-12-21T21:32:47ZengBMCTropical Medicine and Health1349-41472020-12-014811810.1186/s41182-020-00284-xA literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patientsSaber Soltani0Armin Zakeri1Alireza Tabibzadeh2Milad Zandi3Elham Ershadi4Sara Akhavan Rezayat5Sanaz Khaseb6Amir mohammad Zakeri7Mohammadvala Ashtar Nakhaei8Shervin Afzali9Abbas Farahani10Department of Virology, School of Public Health, Tehran University of Medical SciencesDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Virology, Iran University of Medical SciencesDepartment of Virology, School of Public Health, Tehran University of Medical SciencesDepartment of Virology, School of Public Health, Tehran University of Medical SciencesDepartment of Health Care Management and Economics, School of Public Health, Tehran University of Medical SciencesDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares UniversityPediatric Surgery Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical SciencesDepartment of Cellular and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.CDepartment of Cellular and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.CInfectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical SciencesAbstract Background Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. We summarize current knowledge about the prevalence rates of the parvovirus B19 infection in sickle cell anemia and thalassemia patients. Methods Several online databases were searched including, Scopus, EMBASE, Web of Science, Google Scholar, and PubMed, which were performed amidst 2009–2019 by using distinct keywords: “Thalassemia,” “Parvovirus,” “Anemia,” “Sickle cell anemia,” “parvoviridae,” “parvoviridae infection,” and “parvovirus B19.” Results Search results indicated 4 and 7 studies for the prevalence of the parvovirus B19 in β-thalassemia and SCD, respectively. Among the β-thalassemia patients, the B19V seroprevalence for IgG and IgM were ranged from 18.2–81% and 14.5–41.1%, respectively; meanwhile, B19V DNA positively results was 4–15.3%. Moreover, in the SCD group, the extent of B19V IgG was varied from 37.6 to 65.9% and that of IgM was in a range of 2.9–30%, and the DNA detection rate was 4–54%. Conclusion B19V seroprevalence changes in several conditions including, different epidemiological features, socio-economic status, and overpopulation. Age can expand the incidence of anti-B19V IgG/IgM in SCD and beta-thalassemia patients. Reinfection and diverse genotypes are relevant factors in the seroprevalence of B19v. The patients’ immunological-hematological station and higher abundance of transfusions can affect the B19V seroprevalence in SCD and beta-thalassemia group. Further investigations in this field could be suggested to better understand the virus distribution in this susceptible population of patients.https://doi.org/10.1186/s41182-020-00284-xParvovirus B19Sickle cell anemiaβ-thalassemia |
| spellingShingle | Saber Soltani Armin Zakeri Alireza Tabibzadeh Milad Zandi Elham Ershadi Sara Akhavan Rezayat Sanaz Khaseb Amir mohammad Zakeri Mohammadvala Ashtar Nakhaei Shervin Afzali Abbas Farahani A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients Tropical Medicine and Health Parvovirus B19 Sickle cell anemia β-thalassemia |
| title | A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients |
| title_full | A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients |
| title_fullStr | A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients |
| title_full_unstemmed | A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients |
| title_short | A literature review on the parvovirus B19 infection in sickle cell anemia and β-thalassemia patients |
| title_sort | literature review on the parvovirus b19 infection in sickle cell anemia and β thalassemia patients |
| topic | Parvovirus B19 Sickle cell anemia β-thalassemia |
| url | https://doi.org/10.1186/s41182-020-00284-x |
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