Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats
Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2017-11-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.ajol.info/index.php/jasem/article/view/163098 |
| _version_ | 1827296886653976576 |
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| author | P.O. Osarumwense |
| author_facet | P.O. Osarumwense |
| author_sort | P.O. Osarumwense |
| collection | DOAJ |
| description |
Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin.
Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.
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| first_indexed | 2024-04-24T14:46:18Z |
| format | Article |
| id | doaj.art-a2ca2fc2fc7b4002b178178d0a06f6a3 |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T14:46:18Z |
| publishDate | 2017-11-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-a2ca2fc2fc7b4002b178178d0a06f6a32024-04-02T19:55:52ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992017-11-0121610.4314/jasem.v21i6.37Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar ratsP.O. Osarumwense Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract. https://www.ajol.info/index.php/jasem/article/view/163098Citrus SinensisAnti-inflammationCarrageenanPeelsanti-inflammatoryethanolic extract. |
| spellingShingle | P.O. Osarumwense Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats Journal of Applied Sciences and Environmental Management Citrus Sinensis Anti-inflammation Carrageenan Peels anti-inflammatory ethanolic extract. |
| title | Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats |
| title_full | Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats |
| title_fullStr | Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats |
| title_full_unstemmed | Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats |
| title_short | Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of <i>Citrus sinensis</i> peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats |
| title_sort | anti inflammatory activity of methanoilc and ethanolic extracts of i citrus sinensis i peel l osbeck on carrageenan induced paw oedema in wistar rats |
| topic | Citrus Sinensis Anti-inflammation Carrageenan Peels anti-inflammatory ethanolic extract. |
| url | https://www.ajol.info/index.php/jasem/article/view/163098 |
| work_keys_str_mv | AT poosarumwense antiinflammatoryactivityofmethanoilcandethanolicextractsoficitrussinensisipeellosbeckoncarrageenaninducedpawoedemainwistarrats |