Primate homologs of mouse cortico-striatal circuits
With the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across hum...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53680 |
| _version_ | 1811235989723545600 |
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| author | Joshua Henk Balsters Valerio Zerbi Jerome Sallet Nicole Wenderoth Rogier B Mars |
| author_facet | Joshua Henk Balsters Valerio Zerbi Jerome Sallet Nicole Wenderoth Rogier B Mars |
| author_sort | Joshua Henk Balsters |
| collection | DOAJ |
| description | With the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species. Our results suggest that the connectivity patterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were conserved across species, making them reliable targets for cross-species comparisons. However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned). These unassigned voxels were localised to the caudate nucleus and anterior putamen, overlapping with executive function and social/language regions of the striatum and connected to prefrontal-projecting cerebellar lobules and anterior prefrontal cortex, forming circuits that seem to be unique for non-human primates and humans. |
| first_indexed | 2024-04-12T12:01:35Z |
| format | Article |
| id | doaj.art-a2ca4999f9064f20a1de3804a934029b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:01:35Z |
| publishDate | 2020-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a2ca4999f9064f20a1de3804a934029b2022-12-22T03:33:50ZengeLife Sciences Publications LtdeLife2050-084X2020-04-01910.7554/eLife.53680Primate homologs of mouse cortico-striatal circuitsJoshua Henk Balsters0https://orcid.org/0000-0001-9856-6990Valerio Zerbi1https://orcid.org/0000-0001-7984-9565Jerome Sallet2https://orcid.org/0000-0002-7878-0209Nicole Wenderoth3https://orcid.org/0000-0002-3246-9386Rogier B Mars4https://orcid.org/0000-0001-6302-8631Department of Psychology, Royal Holloway University of London, Egham, United Kingdom; Neural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, SwitzerlandNeural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, SwitzerlandWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, Oxford, United KingdomNeural Control of Movement Laboratory, Department of Health Sciences and Technology, ETH Zurich, SwitzerlandWellcome Centre for Integrative Neuroimaging, Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NetherlandsWith the increasing necessity of animal models in biomedical research, there is a vital need to harmonise findings across species by establishing similarities and differences in rodent and primate neuroanatomy. Using connectivity fingerprint matching, we compared cortico-striatal circuits across humans, non-human primates, and mice using resting-state fMRI data in all species. Our results suggest that the connectivity patterns for the nucleus accumbens and cortico-striatal motor circuits (posterior/lateral putamen) were conserved across species, making them reliable targets for cross-species comparisons. However, a large number of human and macaque striatal voxels were not matched to any mouse cortico-striatal circuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned). These unassigned voxels were localised to the caudate nucleus and anterior putamen, overlapping with executive function and social/language regions of the striatum and connected to prefrontal-projecting cerebellar lobules and anterior prefrontal cortex, forming circuits that seem to be unique for non-human primates and humans.https://elifesciences.org/articles/53680connectivityfMRIstriatumconnectivity fingeprint matchingcomparative anatomy |
| spellingShingle | Joshua Henk Balsters Valerio Zerbi Jerome Sallet Nicole Wenderoth Rogier B Mars Primate homologs of mouse cortico-striatal circuits eLife connectivity fMRI striatum connectivity fingeprint matching comparative anatomy |
| title | Primate homologs of mouse cortico-striatal circuits |
| title_full | Primate homologs of mouse cortico-striatal circuits |
| title_fullStr | Primate homologs of mouse cortico-striatal circuits |
| title_full_unstemmed | Primate homologs of mouse cortico-striatal circuits |
| title_short | Primate homologs of mouse cortico-striatal circuits |
| title_sort | primate homologs of mouse cortico striatal circuits |
| topic | connectivity fMRI striatum connectivity fingeprint matching comparative anatomy |
| url | https://elifesciences.org/articles/53680 |
| work_keys_str_mv | AT joshuahenkbalsters primatehomologsofmousecorticostriatalcircuits AT valeriozerbi primatehomologsofmousecorticostriatalcircuits AT jeromesallet primatehomologsofmousecorticostriatalcircuits AT nicolewenderoth primatehomologsofmousecorticostriatalcircuits AT rogierbmars primatehomologsofmousecorticostriatalcircuits |