The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles
Background: The ultrasound parameters such as intensity and time of radiation play an important role in cellular degradation. In this study, the effect of ultrasound radiation parameters on the degradation of 4T1 cells in the presence of gold nanoparticles was investigated. Methods: The 4T1 cells w...
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| Format: | Article |
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Isfahan University of Medical Sciences
2018-07-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/10334 |
| _version_ | 1797724130375630848 |
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| author | Ahmad Shanei Mohammad Reza Salamat Hossein Hejazi Marziyeh Mirzaeiyan |
| author_facet | Ahmad Shanei Mohammad Reza Salamat Hossein Hejazi Marziyeh Mirzaeiyan |
| author_sort | Ahmad Shanei |
| collection | DOAJ |
| description | Background: The ultrasound parameters such as intensity and time of radiation play an important role in cellular degradation. In this study, the effect of ultrasound radiation parameters on the degradation of 4T1 cells in the presence of gold nanoparticles was investigated.
Methods: The 4T1 cells were cultured. The cells were divided into 4 groups including control, gold nanoparticle, ultrasound alone, and ultrasound at the presence of gold nanoparticle. Ultrasound irradiation were performed on the cells at intensity of 0.5, 1.0, and 1.5 W/cm2, for 1, 1.5, and 2 minutes. The viability of cells was determined using MTT assay.
Findings: There was a significant difference in cell viability between the ultrasound and gold nanoparticle group and the other groups at intensity of 1.0 and 1.5 W/cm2. Moreover, there was a significant difference between the ultrasound alone and the control groups at intensity of 1.0 and 1.5 W/cm2.
Conclusion: Using ultrasound in the presence of gold nanoparticles increase cell death via increasing nuclei cavitation phenomenon. |
| first_indexed | 2024-03-12T10:12:58Z |
| format | Article |
| id | doaj.art-a2cc3f97d187481fa265336d6d6b9fdf |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T10:12:58Z |
| publishDate | 2018-07-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-a2cc3f97d187481fa265336d6d6b9fdf2023-09-02T10:43:56ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-07-013647952452910.22122/jims.v36i479.103342983The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold NanoparticlesAhmad Shanei0Mohammad Reza Salamat1Hossein Hejazi2Marziyeh Mirzaeiyan3Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMSc Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: The ultrasound parameters such as intensity and time of radiation play an important role in cellular degradation. In this study, the effect of ultrasound radiation parameters on the degradation of 4T1 cells in the presence of gold nanoparticles was investigated. Methods: The 4T1 cells were cultured. The cells were divided into 4 groups including control, gold nanoparticle, ultrasound alone, and ultrasound at the presence of gold nanoparticle. Ultrasound irradiation were performed on the cells at intensity of 0.5, 1.0, and 1.5 W/cm2, for 1, 1.5, and 2 minutes. The viability of cells was determined using MTT assay. Findings: There was a significant difference in cell viability between the ultrasound and gold nanoparticle group and the other groups at intensity of 1.0 and 1.5 W/cm2. Moreover, there was a significant difference between the ultrasound alone and the control groups at intensity of 1.0 and 1.5 W/cm2. Conclusion: Using ultrasound in the presence of gold nanoparticles increase cell death via increasing nuclei cavitation phenomenon.http://jims.mui.ac.ir/index.php/jims/article/view/10334Radiation injuriesUltrasound radiationMetal nanoparticlesGoldTumor cell line |
| spellingShingle | Ahmad Shanei Mohammad Reza Salamat Hossein Hejazi Marziyeh Mirzaeiyan The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles مجله دانشکده پزشکی اصفهان Radiation injuries Ultrasound radiation Metal nanoparticles Gold Tumor cell line |
| title | The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles |
| title_full | The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles |
| title_fullStr | The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles |
| title_full_unstemmed | The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles |
| title_short | The Effect of Ultrasound Parameters on the Destruction of 4T1 Cells in the Presence of Gold Nanoparticles |
| title_sort | effect of ultrasound parameters on the destruction of 4t1 cells in the presence of gold nanoparticles |
| topic | Radiation injuries Ultrasound radiation Metal nanoparticles Gold Tumor cell line |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/10334 |
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