Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22863-0 |
| _version_ | 1819129419479908352 |
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| author | Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson |
| author_facet | Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson |
| author_sort | Xuan Sun |
| collection | DOAJ |
| description | Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state. |
| first_indexed | 2024-12-22T08:43:25Z |
| format | Article |
| id | doaj.art-a2cd09ff347c4623848c6acc6789d348 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:43:25Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a2cd09ff347c4623848c6acc6789d3482022-12-21T18:32:11ZengNature PortfolioNature Communications2041-17232021-05-0112111710.1038/s41467-021-22863-0Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cellsXuan Sun0Benjamin Cao1Marina Naval-Sanchez2Tony Pham3Yu Bo Yang Sun4Brenda Williams5Shen Y. Heazlewood6Nikita Deshpande7Jinhua Li8Felix Kraus9James Rae10Quan Nguyen11Hamed Yari12Jan Schröder13Chad K. Heazlewood14Madeline Fulton15Jessica Hatwell-Humble16Kaustav Das Gupta17Ronan Kapetanovic18Xiaoli Chen19Matthew J. Sweet20Robert G. Parton21Michael T. Ryan22Jose M. Polo23Christian M. Nefzger24Susan K. Nilsson25Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandAustralian Regenerative Medicine Institute, Monash UniversityBiomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Institute for Molecular Bioscience, The University of QueenslandMonash Biomedicine Discovery InstituteMonash Biomedicine Discovery InstituteInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandAustralian Regenerative Medicine Institute, Monash UniversityBiomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Biomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandMonash Biomedicine Discovery InstituteAustralian Regenerative Medicine Institute, Monash UniversityAustralian Regenerative Medicine Institute, Monash UniversityBiomedical Manufacturing Commonwealth Scientific and Industrial Research Organisation (CSIRO)Aged hematopoietic stem cells (HSC) are characterised by reduced regenerative potential and a loss of quiescence. Here, the authors show nicotinamide riboside treatment shrinks the age-enlarged stem cell pool and shifts aged HSC functionally, metabolically and molecularly towards the young state.https://doi.org/10.1038/s41467-021-22863-0 |
| spellingShingle | Xuan Sun Benjamin Cao Marina Naval-Sanchez Tony Pham Yu Bo Yang Sun Brenda Williams Shen Y. Heazlewood Nikita Deshpande Jinhua Li Felix Kraus James Rae Quan Nguyen Hamed Yari Jan Schröder Chad K. Heazlewood Madeline Fulton Jessica Hatwell-Humble Kaustav Das Gupta Ronan Kapetanovic Xiaoli Chen Matthew J. Sweet Robert G. Parton Michael T. Ryan Jose M. Polo Christian M. Nefzger Susan K. Nilsson Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells Nature Communications |
| title | Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells |
| title_full | Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells |
| title_fullStr | Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells |
| title_full_unstemmed | Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells |
| title_short | Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells |
| title_sort | nicotinamide riboside attenuates age associated metabolic and functional changes in hematopoietic stem cells |
| url | https://doi.org/10.1038/s41467-021-22863-0 |
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