Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review
Immune checkpoint inhibitors (ICIs) have emerged as a powerful and efficacious therapeutic approach for many cancer patients. Sintilimab is a fully human IgG4 monoclonal antibody that binds with programmed cell death receptor-1 (PD-1) to block its interaction with ligands, thereby enhancing the anti...
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MDPI AG
2023-10-01
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author | Xin Liu Ziyue Zeng Jianlei Cao Xianqing Li Muheremu Muhetaer Zhili Jin Huanhuan Cai Zhibing Lu |
author_facet | Xin Liu Ziyue Zeng Jianlei Cao Xianqing Li Muheremu Muhetaer Zhili Jin Huanhuan Cai Zhibing Lu |
author_sort | Xin Liu |
collection | DOAJ |
description | Immune checkpoint inhibitors (ICIs) have emerged as a powerful and efficacious therapeutic approach for many cancer patients. Sintilimab is a fully human IgG4 monoclonal antibody that binds with programmed cell death receptor-1 (PD-1) to block its interaction with ligands, thereby enhancing the antitumor effects of T cells. However, ICIs may induce immune-related adverse events (irAEs) in various systems and organs, with fulminant myocarditis being the most severe one. We report the case of a 45-year-old female with gastric cancer who developed chest pain two weeks after chemotherapy with sintilimab; she was diagnosed with immune-associated fulminant myocarditis and experienced an Adams–Stokes syndrome attack in the hospital. Eventually, she was discharged after being treated with methylprednisolone, immunoglobulin, and an IABP. |
first_indexed | 2024-03-10T21:11:01Z |
format | Article |
id | doaj.art-a2ce27d526704e8bbbc8164c18978ac7 |
institution | Directory Open Access Journal |
issn | 2308-3425 |
language | English |
last_indexed | 2024-03-10T21:11:01Z |
publishDate | 2023-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Cardiovascular Development and Disease |
spelling | doaj.art-a2ce27d526704e8bbbc8164c18978ac72023-11-19T16:50:44ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-10-01101042210.3390/jcdd10100422Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature ReviewXin Liu0Ziyue Zeng1Jianlei Cao2Xianqing Li3Muheremu Muhetaer4Zhili Jin5Huanhuan Cai6Zhibing Lu7Department of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaDepartment of Cardiology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, ChinaImmune checkpoint inhibitors (ICIs) have emerged as a powerful and efficacious therapeutic approach for many cancer patients. Sintilimab is a fully human IgG4 monoclonal antibody that binds with programmed cell death receptor-1 (PD-1) to block its interaction with ligands, thereby enhancing the antitumor effects of T cells. However, ICIs may induce immune-related adverse events (irAEs) in various systems and organs, with fulminant myocarditis being the most severe one. We report the case of a 45-year-old female with gastric cancer who developed chest pain two weeks after chemotherapy with sintilimab; she was diagnosed with immune-associated fulminant myocarditis and experienced an Adams–Stokes syndrome attack in the hospital. Eventually, she was discharged after being treated with methylprednisolone, immunoglobulin, and an IABP.https://www.mdpi.com/2308-3425/10/10/422gastric cancerimmune checkpoint inhibitorprogrammed cell death receptor-1sintilimabmyocarditis |
spellingShingle | Xin Liu Ziyue Zeng Jianlei Cao Xianqing Li Muheremu Muhetaer Zhili Jin Huanhuan Cai Zhibing Lu Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review Journal of Cardiovascular Development and Disease gastric cancer immune checkpoint inhibitor programmed cell death receptor-1 sintilimab myocarditis |
title | Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review |
title_full | Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review |
title_fullStr | Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review |
title_full_unstemmed | Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review |
title_short | Sintilimab-Induced Myocarditis in a Patient with Gastric Cancer: A Case Report and Literature Review |
title_sort | sintilimab induced myocarditis in a patient with gastric cancer a case report and literature review |
topic | gastric cancer immune checkpoint inhibitor programmed cell death receptor-1 sintilimab myocarditis |
url | https://www.mdpi.com/2308-3425/10/10/422 |
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