IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model

Aging is a major risk factor for Alzheimer’s disease (AD). Insulin-like growth factor-1 receptor (IGF-1R) regulates general aging and lifespan. However, the contribution of IGF-1 to age-related AD pathology and progression is highly controversial. Based on our previous work, AβPP/PS1 double transgen...

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Bibliographic Details
Main Authors: Mona Sohrabi, Angela M. Floden, Gunjan D. Manocha, Marilyn G. Klug, Colin K. Combs
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
neuroinflammation
Aβ
trophic factor
picropodophyllin
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00200/full

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