Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study
BackgroundThe Seoul Pluripotent Risk for Mental Illness (SPRIM) study was designed to identify predictors leading to mental illness in help-seeking individuals by securing sufficient statistical power through transdiagnostic approaches. The SPRIM study aims to examine the clinical characteristics of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00340/full |
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| author | Tae Young Lee Junhee Lee Hyun Ju Lee Yunna Lee Sang Jin Rhee Dong Yeon Park Myung Jae Paek Eun Young Kim Euitae Kim Sungwon Roh Hee Yeon Jung Minah Kim Se Hyun Kim Dohyun Han Yong Min Ahn Kyooseob Ha Jun Soo Kwon |
| author_facet | Tae Young Lee Junhee Lee Hyun Ju Lee Yunna Lee Sang Jin Rhee Dong Yeon Park Myung Jae Paek Eun Young Kim Euitae Kim Sungwon Roh Hee Yeon Jung Minah Kim Se Hyun Kim Dohyun Han Yong Min Ahn Kyooseob Ha Jun Soo Kwon |
| author_sort | Tae Young Lee |
| collection | DOAJ |
| description | BackgroundThe Seoul Pluripotent Risk for Mental Illness (SPRIM) study was designed to identify predictors leading to mental illness in help-seeking individuals by securing sufficient statistical power through transdiagnostic approaches. The SPRIM study aims to examine the clinical characteristics of high-risk individuals for mental illness and to identify proteomic biomarkers that can predict the onset of mental illness.MethodsThis paper describes the study protocol of the SPRIM study. We aim to recruit 150 participants who meet the criteria for high risk for major mental illness, 150 patients with major psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder), and 50 matched healthy control subjects for 2 years. Clinical evaluations, self-report measures, and proteomic analyses will be implemented. The assessment points are at baseline, 6, 12, 18, and 24 months.ConclusionsIn the present study, we introduced the study protocol of the SPRIM study, which is the first prospective cohort study of transdiagnostic high-risk concepts using proteomic biomarkers. This study has a paradigm that encompasses various diseases without aiming at predicting and preventing the development of a specific mental illness in help-seeking individuals. The transdiagnostic high-risk concept could be extended to provide a perspective for people with various psychopathological tendencies below a threshold, such that they do not meet the existing diagnostic criteria of mental illnesses, to determine what may lead them to a specific disease and help identify appropriate preventative interventions. |
| first_indexed | 2024-04-13T03:03:21Z |
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| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T03:03:21Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a2d293c7ae8c4140a1ed6f878844cc5c2022-12-22T03:05:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-04-011110.3389/fpsyt.2020.00340512870Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness StudyTae Young Lee0Junhee Lee1Hyun Ju Lee2Yunna Lee3Sang Jin Rhee4Dong Yeon Park5Myung Jae Paek6Eun Young Kim7Euitae Kim8Sungwon Roh9Hee Yeon Jung10Minah Kim11Se Hyun Kim12Dohyun Han13Yong Min Ahn14Kyooseob Ha15Jun Soo Kwon16Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Kosin University Gospel Hospital, Pusan, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Psychiatry, National Center for Mental Health, Seoul, South KoreaDepartment of Psychiatry, The Armed Forces Capital Hospital, Seongnam, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Neuropsychiatry, Hanyang University Hospital, Seoul, South KoreaDepartment of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South KoreaBackgroundThe Seoul Pluripotent Risk for Mental Illness (SPRIM) study was designed to identify predictors leading to mental illness in help-seeking individuals by securing sufficient statistical power through transdiagnostic approaches. The SPRIM study aims to examine the clinical characteristics of high-risk individuals for mental illness and to identify proteomic biomarkers that can predict the onset of mental illness.MethodsThis paper describes the study protocol of the SPRIM study. We aim to recruit 150 participants who meet the criteria for high risk for major mental illness, 150 patients with major psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder), and 50 matched healthy control subjects for 2 years. Clinical evaluations, self-report measures, and proteomic analyses will be implemented. The assessment points are at baseline, 6, 12, 18, and 24 months.ConclusionsIn the present study, we introduced the study protocol of the SPRIM study, which is the first prospective cohort study of transdiagnostic high-risk concepts using proteomic biomarkers. This study has a paradigm that encompasses various diseases without aiming at predicting and preventing the development of a specific mental illness in help-seeking individuals. The transdiagnostic high-risk concept could be extended to provide a perspective for people with various psychopathological tendencies below a threshold, such that they do not meet the existing diagnostic criteria of mental illnesses, to determine what may lead them to a specific disease and help identify appropriate preventative interventions.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00340/fullbipolar disorderhigh-risk for mental illnessmajor depressive disorderpluripotentialproteomicsschizophrenia |
| spellingShingle | Tae Young Lee Junhee Lee Hyun Ju Lee Yunna Lee Sang Jin Rhee Dong Yeon Park Myung Jae Paek Eun Young Kim Euitae Kim Sungwon Roh Hee Yeon Jung Minah Kim Se Hyun Kim Dohyun Han Yong Min Ahn Kyooseob Ha Jun Soo Kwon Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study Frontiers in Psychiatry bipolar disorder high-risk for mental illness major depressive disorder pluripotential proteomics schizophrenia |
| title | Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study |
| title_full | Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study |
| title_fullStr | Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study |
| title_full_unstemmed | Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study |
| title_short | Study Protocol for a Prospective Longitudinal Cohort Study to Identify Proteomic Predictors of Pluripotent Risk for Mental Illness: The Seoul Pluripotent Risk for Mental Illness Study |
| title_sort | study protocol for a prospective longitudinal cohort study to identify proteomic predictors of pluripotent risk for mental illness the seoul pluripotent risk for mental illness study |
| topic | bipolar disorder high-risk for mental illness major depressive disorder pluripotential proteomics schizophrenia |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00340/full |
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