Exercise increases serum fibroblast growth factor 21 (FGF21) levels.
Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise.This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily s...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3365112?pdf=render |
| _version_ | 1818128887898439680 |
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| author | Daniel Cuevas-Ramos Paloma Almeda-Valdés Clara Elena Meza-Arana Griselda Brito-Córdova Francisco J Gómez-Pérez Roopa Mehta Jorge Oseguera-Moguel Carlos A Aguilar-Salinas |
| author_facet | Daniel Cuevas-Ramos Paloma Almeda-Valdés Clara Elena Meza-Arana Griselda Brito-Córdova Francisco J Gómez-Pérez Roopa Mehta Jorge Oseguera-Moguel Carlos A Aguilar-Salinas |
| author_sort | Daniel Cuevas-Ramos |
| collection | DOAJ |
| description | Fibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise.This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24±3.7 years old, and the mean BMI was 21.4±7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p<0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p<0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p<0.0001) and delta plasma FFAs (r = 0.35, p = 0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F = 4.32; r² = 0.64, p<0.0001).Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise.ClinicalTrials.gov NCT01512368. |
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| id | doaj.art-a2d3715f636548a0a5b073a8c5d8bf4a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T07:40:24Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-a2d3715f636548a0a5b073a8c5d8bf4a2022-12-22T01:15:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3802210.1371/journal.pone.0038022Exercise increases serum fibroblast growth factor 21 (FGF21) levels.Daniel Cuevas-RamosPaloma Almeda-ValdésClara Elena Meza-AranaGriselda Brito-CórdovaFrancisco J Gómez-PérezRoopa MehtaJorge Oseguera-MoguelCarlos A Aguilar-SalinasFibroblast growth factor 21 (FGF21) increases glucose uptake. It is unknown if FGF21 serum levels are affected by exercise.This was a comparative longitudinal study. Anthropometric and biochemical evaluation were carried out before and after a bout of exercise and repeated after two weeks of daily supervised exercise. The study sample was composed of 60 sedentary young healthy women. The mean age was 24±3.7 years old, and the mean BMI was 21.4±7.0 kg/m². The anthropometric characteristics did not change after two weeks of exercise. FGF21 levels significantly increased after two weeks of exercise (276.8 ng/l (142.8-568.6) vs. (460.8 (298.2-742.1), p<0.0001)). The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p<0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p<0.0001) and delta plasma FFAs (r = 0.35, p = 0.006). A stepwise linear regression model showed that glucose, MHR, METs, FFAs, and epinephrine, were factors independently associated with the increment in FGF21 after the exercise program (F = 4.32; r² = 0.64, p<0.0001).Serum FGF21 levels significantly increased after two weeks of physical activity. This increment correlated positively with clinical parameters related to the adrenergic and lipolytic response to exercise.ClinicalTrials.gov NCT01512368.http://europepmc.org/articles/PMC3365112?pdf=render |
| spellingShingle | Daniel Cuevas-Ramos Paloma Almeda-Valdés Clara Elena Meza-Arana Griselda Brito-Córdova Francisco J Gómez-Pérez Roopa Mehta Jorge Oseguera-Moguel Carlos A Aguilar-Salinas Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS ONE |
| title | Exercise increases serum fibroblast growth factor 21 (FGF21) levels. |
| title_full | Exercise increases serum fibroblast growth factor 21 (FGF21) levels. |
| title_fullStr | Exercise increases serum fibroblast growth factor 21 (FGF21) levels. |
| title_full_unstemmed | Exercise increases serum fibroblast growth factor 21 (FGF21) levels. |
| title_short | Exercise increases serum fibroblast growth factor 21 (FGF21) levels. |
| title_sort | exercise increases serum fibroblast growth factor 21 fgf21 levels |
| url | http://europepmc.org/articles/PMC3365112?pdf=render |
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