A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Bioanalytical Method for the Quantification of Encorafenib and Binimetinib as a First-Line Treatment for Advanced (Unresectable or Metastatic) Melanoma—Application to a Pharmacokinetic Study

A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Bioanalytical Method for the Quantification of Encorafenib and Binimetinib as a First-Line Treatment for Advanced (Unresectable or Metastatic) Melanoma—Application to a Pharmacokinetic Study

The combination regimen targeting BRAF and MEK inhibition, for instance, encorafenib (Braftovi<sup>™</sup>, ENF) plus binimetinib (Mektovi<sup>®</sup>, BNB), are now recommended as first-line treatment in patients with unresectable or metastatic melanoma with a BRAF V600-acti...

Full description

Bibliographic Details
Main Authors:	Mohamed M. Hefnawy, Mohammed M. Alanazi, Abdullah M. Al-Hossaini, Abdulaziz I. Alnasser, Adel S. El-Azab, Yousef A. Bin Jardan, Mohamed W. Attwa, Manal A. El-Gendy
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Molecules
Subjects:	LC–MS/MS melanoma encorafenib binimetinib rat plasma pharmacokinetics
Online Access:	https://www.mdpi.com/1420-3049/28/1/79

Similar Items

A Validated LC–MS/MS Assay for the Simultaneous Quantification of the FDA-Approved Anticancer Mixture (Encorafenib and Binimetinib): Metabolic Stability Estimation
by: Mohamed W. Attwa, et al.
Published: (2021-05-01)

Sweet syndrome in a patient receiving encorafenib and binimetinib therapy for malignant melanoma
by: Myiah Quach, BS, et al.
Published: (2024-03-01)

BAYONET trial: staged combination with encorafenib, binimetinib, plus cetuximab following encorafenib plus cetuximab for BRAF V600E-mutant metastatic colorectal cancer
by: Y. Matsubara, et al.
Published: (2024-06-01)

Tumor lysis syndrome signal with the combination of encorafenib and binimetinib for malignant melanoma: a pharmacovigilance study using data from the FAERS database
by: Shuang Xia, et al.
Published: (2024-09-01)

Cost-effectiveness analysis of encorafenib and binimetinib combination as first-line treatment for metastatic or unresectable <i>BRAF</i> V600-mutated metastatic melanoma in Russia
by: N. A. Avxentyev, et al.
Published: (2023-11-01)

BRAF V600E-mutant colorectal cancer with CNS metastases treated successfully with encorafenib, binimetinib and cetuximab
by: Toru Imai, et al.
Published: (2024-12-01)

NEXUS trial: a multicenter phase II clinical study evaluating the efficacy and safety of the perioperative use of encorafenib, binimetinib, and cetuximab in patients with previously untreated surgically resectable BRAF V600E mutant colorectal oligometastases
by: Shin Kobayashi, et al.
Published: (2023-08-01)

Eruptive Melanocytic Nevi in the Setting of Encorafenib, Cetuximab, and Binimetinib Combination Therapy: A Case Report
by: Karen Lam, et al.
Published: (2024-05-01)

Severe Colitis in 2 Patients with Melanoma Treated with BRAF/MEK Inhibitors: Case Report and Literature Review
by: Chloe Wautier, et al.
Published: (2024-02-01)

Eruptive nevi in the setting of encorafenib: A case report and literature review
by: Marisa Lenga, BS, et al.
Published: (2025-02-01)

A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-methyl Metabolite in Plasma: Application to a Pharmacokinetic Study
by: Mohamed M. Hefnawy, et al.
Published: (2023-02-01)

Applicable Pharmacokinetic Study: Development and Validation of Bioanalytical LC-MS/MS Method for Simultaneous Determination of Tipiracil, Trifluridine and Its Two Metabolites 5-Trifluoromethyluracil, 5-Carboxy 2′-Deoxyuridine in Rat Plasma
by: Manal El-Gendy, et al.
Published: (2023-12-01)

The safety and efficacy of binimetinib for lung cancer: a systematic review
by: Mahdi Zahmatyar, et al.
Published: (2024-08-01)

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF<sup>V600E</sup> Protein
by: Elisabetta Marini, et al.
Published: (2022-12-01)

Binimetinib in combination with nivolumab or nivolumab and ipilimumab in patients with previously treated microsatellite-stable metastatic colorectal cancer with RAS mutations in an open-label phase 1b/2 study
by: Elena Elez, et al.
Published: (2024-04-01)

Case report: Parsonage-turner syndrome in a melanoma patient treated by BRAF/MEK inhibitors after immune checkpoint inhibitors
by: Charlotte Bonnefin, et al.
Published: (2023-12-01)

Second-generation BRAF inhibitor Encorafenib resistance is regulated by NCOA4-mediated iron trafficking in the drug-resistant malignant melanoma cells
by: Ceyda Colakoglu Bergel, et al.
Published: (2025-01-01)

Encorafenib Acts as a Dual-Activity Chemosensitizer through Its Inhibitory Effect on ABCC1 Transporter In Vitro and Ex Vivo
by: Yu Zhang, et al.
Published: (2022-11-01)

Severe Drug-Induced Liver Injury from Combination Encorafenib/Binimetinib
by: Nicholas Gravbrot, et al.
Published: (2019-01-01)

Fast and Sensitive Bioanalytical Method for the Determination of Deucravacitinib in Human Plasma Using HPLC-MS/MS: Application and Greenness Evaluation
by: Pottabattula Mahesh, et al.
Published: (2023-07-01)

An UPLC–ESI–MS/MS Bioanalytical Methodology for the Quantification of Gilteritinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation
by: Mohamed W. Attwa, et al.
Published: (2023-04-01)

3075 Guillain-Barré syndrome following treatment with binimetinib and encorafenib for metastatic melanoma
by: Michael Hayes, et al.
Published: (2024-08-01)

Development and Validation of a Bioanalytical Method for 3′- and 6′-Sialyllactose in Minipig Liver and Kidney Using Liquid Chromatography-Tandem Mass Spectrometry and Its Application to Analysis of Tissue Distribution
by: Han Young Eom, et al.
Published: (2020-12-01)

Development and Validation of High-Throughput Bioanalytical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantification of Newly Synthesized Antitumor Carbonic Anhydrase Inhibitors in Human Plasma
by: Ahmed M. Abdel-Megied, et al.
Published: (2020-12-01)

Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
by: Pridhvi Krishna Gaddey, et al.
Published: (2024-04-01)

Bioanalytical method validation for therapeutic drug monitoring of olaparib in patients with ovarian cancer
by: Konrad Lewandowski, et al.
Published: (2024-06-01)

Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation
by: Mohamed W. Attwa, et al.
Published: (2023-02-01)

Advancing Bioanalytical Method Validation: A Comprehensive ICH M10 Approach for Validating LC–MS/MS to Quantify Fluoxetine in Human Plasma and Its Application in Pharmacokinetic Studies
by: Aimen El Orche, et al.
Published: (2024-09-01)

Insights into <i>Clematis cirrhosa</i> L. Ethanol Extract: Cytotoxic Effects, LC-ESI-QTOF-MS/MS Chemical Profiling, Molecular Docking, and Acute Toxicity Study
by: Manal I. Alruwad, et al.
Published: (2024-10-01)

Real-life evidence of encorafenib plus binimetinib in patients with unresectable advanced or metastatic BRAFV600-mutant melanoma in Spain: the BECARE (GEM-2002) trial
by: Ainara Soria, et al.
Published: (2025-02-01)

Tandem mass spectrometry imaging to assess illudin S distributions in Omphalotus illudens mushrooms
by: Shigeki Matsui, et al.
Published: (2024-12-01)

Bioanalytical method for the simultaneous estimation of atoltivimab, maftivimab and odesivimab in rat plasma by LCMS/MS and its application to a pharmacokinetic study
by: Ibrahim Baje Syed, et al.
Published: (2024-08-01)

Bioanalytical method development and validation for the simultaneous estimation of Olanzapine and Samidorphan in rabbit plasma by using HPLC–MS/MS and application to pharmacokinetic study
by: Rambabu Kantipudi, et al.
Published: (2024-01-01)

Simultaneous Method for Selected PBDEs and HBCDDs in Foodstuffs Using Gas Chromatography—Tandem Mass Spectrometry and Liquid Chromatography—Tandem Mass Spectrometry
by: Eva Lipičar, et al.
Published: (2022-12-01)

A Novel UHPLC-MS/MS-Based Bioanalytical Method Developed for S-Allyl Cysteine in the Establishment of a Comparative Pharmacokinetic Study
by: Mohd Faiyaz Khan, et al.
Published: (2023-07-01)

Development of the Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Chloroquine and Desethylchloroquine in Human Plasma
by: Rasda Boonprasert, et al.
Published: (2020-07-01)

Identification of Daphnane Diterpenoids from <i>Wikstroemia indica</i> Using Liquid Chromatography with Tandem Mass Spectrometry
by: Mi Zhang, et al.
Published: (2023-10-01)

Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products
by: Awadh M. Ali, et al.
Published: (2023-11-01)

Bile Acids Quantification by Liquid Chromatography–Tandem Mass Spectrometry: Method Validation, Reference Range, and Interference Study
by: Elisa Danese, et al.
Published: (2020-07-01)

Investigation And Method Optimization For The Determination Of Noscapine And Related Stress Degradation Compounds By Lıquid Chromatography Coupled To Tandem Mass Spectrometry (LCMS/MS)
by: Süleyman Gökçe, et al.
Published: (2017-01-01)