Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07094-0 |
| _version_ | 1819195057729699840 |
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| author | Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki |
| author_facet | Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki |
| author_sort | Wataru Shihoya |
| collection | DOAJ |
| description | Signalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation. |
| first_indexed | 2024-12-23T02:06:43Z |
| format | Article |
| id | doaj.art-a2d527b16f98446e9ee5dcdca8a86e97 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:06:43Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a2d527b16f98446e9ee5dcdca8a86e972022-12-21T18:03:52ZengNature PortfolioNature Communications2041-17232018-11-019111110.1038/s41467-018-07094-0Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activationWataru Shihoya0Tamaki Izume1Asuka Inoue2Keitaro Yamashita3Francois Marie Ngako Kadji4Kunio Hirata5Junken Aoki6Tomohiro Nishizawa7Osamu Nureki8Department of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoGraduate School of Pharmaceutical Sciences, Tohoku UniversityDepartment of Biological Sciences, Graduate School of Science, The University of TokyoGraduate School of Pharmaceutical Sciences, Tohoku UniversityRIKEN SPring-8 CenterGraduate School of Pharmaceutical Sciences, Tohoku UniversityDepartment of Biological Sciences, Graduate School of Science, The University of TokyoDepartment of Biological Sciences, Graduate School of Science, The University of TokyoSignalling through the endothelin receptor ETB, a class A GPCR, induces nitric oxide-mediated vasorelaxation. Here the authors present the crystal structures of the human ETB receptor bound to the peptide hormone endothelin-3 and in complex with the ETB-selective partial agonist IRL1620 and discuss mechanistic implications for receptor activation.https://doi.org/10.1038/s41467-018-07094-0 |
| spellingShingle | Wataru Shihoya Tamaki Izume Asuka Inoue Keitaro Yamashita Francois Marie Ngako Kadji Kunio Hirata Junken Aoki Tomohiro Nishizawa Osamu Nureki Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation Nature Communications |
| title | Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation |
| title_full | Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation |
| title_fullStr | Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation |
| title_full_unstemmed | Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation |
| title_short | Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation |
| title_sort | crystal structures of human etb receptor provide mechanistic insight into receptor activation and partial activation |
| url | https://doi.org/10.1038/s41467-018-07094-0 |
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