Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies
Objective: To study the beneficial effects of thyroid replacement therapy (TRT) on pregnancy outcomes in patients with subclinical hypothyroidism (SCl hypoT) with respect to thyroid peroxidase (TPO) autoantibodies. Design: Retrospective study of 706 patients. Setting: Not applicable. Patient(s): The...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | F&S Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334121001252 |
| _version_ | 1818992417802551296 |
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| author | Himanshu Arora, Ph.D. Ineabelle Collazo, B.S. Katherine L. Palmerola, M.D. Madhumita Parmar, B.S. Manish Narasimman, B.S. Nicholas Hendon, B.S. Juergen Eisermann, M.D. Maria Bustillo, M.D. |
| author_facet | Himanshu Arora, Ph.D. Ineabelle Collazo, B.S. Katherine L. Palmerola, M.D. Madhumita Parmar, B.S. Manish Narasimman, B.S. Nicholas Hendon, B.S. Juergen Eisermann, M.D. Maria Bustillo, M.D. |
| author_sort | Himanshu Arora, Ph.D. |
| collection | DOAJ |
| description | Objective: To study the beneficial effects of thyroid replacement therapy (TRT) on pregnancy outcomes in patients with subclinical hypothyroidism (SCl hypoT) with respect to thyroid peroxidase (TPO) autoantibodies. Design: Retrospective study of 706 patients. Setting: Not applicable. Patient(s): The study evaluated 706 patients, who were divided into 3 cohorts: euthyroid patients, with pre–in vitro fertilization thyroid-stimulating hormone levels of <2.5 μIU/mL; patients with SCl hypoT, defined as thyroid-stimulating hormone levels of >2.5 μIU/mL and <4 μIU/mL, who were not treated; and patients with SCl hypoT who received TRT. The 3 cohorts were further subclassified into 2 groups, each based on TPO antibody levels. Intervention(s): The cohorts were compared for the effects of TRT on pregnancy outcomes. Main Outcome Measure(s): Identification of effects of TRT on assisted reproductive technology outcomes. Result(s): Patients with SCl hypoT had significantly fewer positive pregnancy outcomes than euthyroid patients. Importantly, low-dose TRT was found to be beneficial in improving IVF success and pregnancy outcomes in patients with SCl hypoT. The original cohort of patients, further classified into 2 subgroups on the basis of antithyroid (TPO) antibodies, showed that low-dose TRT was associated with improved pregnancy outcomes in women with SCl hypoT and TPO-positive antibodies. Conclusion(s): Our findings demonstrate that low-dose TRT may be beneficial in improving in vitro fertilization success and pregnancy outcomes in women with SCl hypoT and TPO-positive antibodies. |
| first_indexed | 2024-12-20T20:25:50Z |
| format | Article |
| id | doaj.art-a2d54c16c7494f5a856de582cdb5317e |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-12-20T20:25:50Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-a2d54c16c7494f5a856de582cdb5317e2022-12-21T19:27:28ZengElsevierF&S Reports2666-33412022-03-01313238Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodiesHimanshu Arora, Ph.D.0Ineabelle Collazo, B.S.1Katherine L. Palmerola, M.D.2Madhumita Parmar, B.S.3Manish Narasimman, B.S.4Nicholas Hendon, B.S.5Juergen Eisermann, M.D.6Maria Bustillo, M.D.7Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida; Reprint requests: Himanshu Arora, Ph.D., Department of Urology, Miller School of Medicine, University of Miami, 1501 NW 10th Ave, Suite 809, Miami, Florida 33136.IVFMD, South Florida Institute for Reproductive Medicine, Miami, FloridaIVFMD, South Florida Institute for Reproductive Medicine, Miami, FloridaDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FloridaDepartment of Urology, Miller School of Medicine, University of Miami, Miami, FloridaIVFMD, South Florida Institute for Reproductive Medicine, Miami, FloridaIVFMD, South Florida Institute for Reproductive Medicine, Miami, FloridaIVFMD, South Florida Institute for Reproductive Medicine, Miami, Florida; Maria Bustillo, M.D., IVFMD, South Florida Institute for Reproductive Medicine, 7300 SW 62nd Place, 4th Floor, Miami, Florida 33143.Objective: To study the beneficial effects of thyroid replacement therapy (TRT) on pregnancy outcomes in patients with subclinical hypothyroidism (SCl hypoT) with respect to thyroid peroxidase (TPO) autoantibodies. Design: Retrospective study of 706 patients. Setting: Not applicable. Patient(s): The study evaluated 706 patients, who were divided into 3 cohorts: euthyroid patients, with pre–in vitro fertilization thyroid-stimulating hormone levels of <2.5 μIU/mL; patients with SCl hypoT, defined as thyroid-stimulating hormone levels of >2.5 μIU/mL and <4 μIU/mL, who were not treated; and patients with SCl hypoT who received TRT. The 3 cohorts were further subclassified into 2 groups, each based on TPO antibody levels. Intervention(s): The cohorts were compared for the effects of TRT on pregnancy outcomes. Main Outcome Measure(s): Identification of effects of TRT on assisted reproductive technology outcomes. Result(s): Patients with SCl hypoT had significantly fewer positive pregnancy outcomes than euthyroid patients. Importantly, low-dose TRT was found to be beneficial in improving IVF success and pregnancy outcomes in patients with SCl hypoT. The original cohort of patients, further classified into 2 subgroups on the basis of antithyroid (TPO) antibodies, showed that low-dose TRT was associated with improved pregnancy outcomes in women with SCl hypoT and TPO-positive antibodies. Conclusion(s): Our findings demonstrate that low-dose TRT may be beneficial in improving in vitro fertilization success and pregnancy outcomes in women with SCl hypoT and TPO-positive antibodies.http://www.sciencedirect.com/science/article/pii/S2666334121001252Subclinical hypothyroidismin vitro fertilizationthyroid replacement therapy |
| spellingShingle | Himanshu Arora, Ph.D. Ineabelle Collazo, B.S. Katherine L. Palmerola, M.D. Madhumita Parmar, B.S. Manish Narasimman, B.S. Nicholas Hendon, B.S. Juergen Eisermann, M.D. Maria Bustillo, M.D. Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies F&S Reports Subclinical hypothyroidism in vitro fertilization thyroid replacement therapy |
| title | Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| title_full | Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| title_fullStr | Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| title_full_unstemmed | Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| title_short | Positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| title_sort | positive effects of thyroid replacement therapy on assisted reproductive technology outcomes in women with subclinical hypothyroidism with positive thyroid peroxidase autoantibodies |
| topic | Subclinical hypothyroidism in vitro fertilization thyroid replacement therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2666334121001252 |
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