ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION
Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2010-06-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/294 |
| Summary: | Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered the mechanism activation of NF-κB in allograft rejection and its role in following pathological processes: endothelial cells activation, recipient T-cells activation and maturation of dendritic cells (antigen – presenting immune cells). NF-κB – targeted therapeutics approaches, that might be effective in transplantation are presented. |
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| ISSN: | 1995-1191 |