ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION
Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2010-06-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/294 |
| _version_ | 1797872087059136512 |
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| author | N. V. Kuncevich |
| author_facet | N. V. Kuncevich |
| author_sort | N. V. Kuncevich |
| collection | DOAJ |
| description | Nuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered the mechanism activation of NF-κB in allograft rejection and its role in following pathological processes: endothelial cells activation, recipient T-cells activation and maturation of dendritic cells (antigen – presenting immune cells). NF-κB – targeted therapeutics approaches, that might be effective in transplantation are presented. |
| first_indexed | 2024-04-10T00:54:26Z |
| format | Article |
| id | doaj.art-a2d5b2f869444ec6a9bcf00a82678381 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:54:26Z |
| publishDate | 2010-06-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-a2d5b2f869444ec6a9bcf00a826783812023-03-13T10:37:20ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912010-06-01121727710.15825/1995-1191-2010-1-72-77237ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTIONN. V. Kuncevich0Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, MoscowNuclear factor kappa B (NF-κB) is a rapid response transcription factor for genes whose products are critical for inflammation and immunity. In this review structure and general properties of NF-κB the role of transcription factor NF-κB in allograft rejection are presented. In this review considered the mechanism activation of NF-κB in allograft rejection and its role in following pathological processes: endothelial cells activation, recipient T-cells activation and maturation of dendritic cells (antigen – presenting immune cells). NF-κB – targeted therapeutics approaches, that might be effective in transplantation are presented.https://journal.transpl.ru/vtio/article/view/294nuclear transcription factor nf-κbtransplant rejectionoxidative stress |
| spellingShingle | N. V. Kuncevich ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION Vestnik Transplantologii i Iskusstvennyh Organov nuclear transcription factor nf-κb transplant rejection oxidative stress |
| title | ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION |
| title_full | ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION |
| title_fullStr | ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION |
| title_full_unstemmed | ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION |
| title_short | ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION |
| title_sort | role of nuclear factor nf κb in allograft rejektion |
| topic | nuclear transcription factor nf-κb transplant rejection oxidative stress |
| url | https://journal.transpl.ru/vtio/article/view/294 |
| work_keys_str_mv | AT nvkuncevich roleofnuclearfactornfkbinallograftrejektion |