WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detect...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.835946/full |
| _version_ | 1828881291242635264 |
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| author | Hongwei Zhao Hongwei Zhao Wenmiao Xu Wenmiao Xu Lijuan Wang Lijuan Wang Yun Zhu Yun Zhu Xiaohui Wang Xiaohui Wang Yingchao Liu Yingchao Liu Junhong Ai Junhong Ai Qianyu Feng Qianyu Feng Li Deng Yun Sun Changchong Li Rong Jin Yunxiao Shang Hengmiao Gao Hengmiao Gao Suyun Qian Suyun Qian Lili Xu Lili Xu Zhengde Xie Zhengde Xie |
| author_facet | Hongwei Zhao Hongwei Zhao Wenmiao Xu Wenmiao Xu Lijuan Wang Lijuan Wang Yun Zhu Yun Zhu Xiaohui Wang Xiaohui Wang Yingchao Liu Yingchao Liu Junhong Ai Junhong Ai Qianyu Feng Qianyu Feng Li Deng Yun Sun Changchong Li Rong Jin Yunxiao Shang Hengmiao Gao Hengmiao Gao Suyun Qian Suyun Qian Lili Xu Lili Xu Zhengde Xie Zhengde Xie |
| author_sort | Hongwei Zhao |
| collection | DOAJ |
| description | WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detected in their nasopharyngeal swabs. Furthermore, we conducted a multicentre study in six hospitals from different districts of China. WUPyV was detected by real-time polymerase chain reaction assays, and the clinical and molecular epidemiological characteristics of WUPyV strains among hospitalized children with acute lower respiratory tract infections all around China from 2017 to 2019 were analysed. Two complete WUPyV genome sequences were assembled from fatal patients’ airway specimens. Phylogenetic tree analysis revealed that they were most closely related to strains derived from Fujian and Chongqing, China, in 2008 and 2013, respectively. In 2017–2019, a total of 1,812 samples from children with acute lower respiratory tract infections were detected for WUPyV, of which 11 (0.6%) were positive. Children aged ≤5 were more susceptible to WUPyV infection. A total of 81.8% of WUPyV-positive patients were coinfected with other viruses, of which rhinovirus enjoyed the highest frequency. The main clinical symptoms of infected patients include fever, coughing and sputum expectoration. Most patients were diagnosed with pneumonia, followed by bronchial surgery. Three patients manifested severe infection, and all patients improved and were discharged. Our results show that WUPyV persistently circulates in China. Further investigations on the clinical role and pathogenicity of WUPyV are necessary. |
| first_indexed | 2024-12-13T10:03:45Z |
| format | Article |
| id | doaj.art-a2d6b6fe36f54d3aad5733e8d18b2f82 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T10:03:45Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-a2d6b6fe36f54d3aad5733e8d18b2f822022-12-21T23:51:35ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-03-011110.3389/fcimb.2021.835946835946WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological SurveyHongwei Zhao0Hongwei Zhao1Wenmiao Xu2Wenmiao Xu3Lijuan Wang4Lijuan Wang5Yun Zhu6Yun Zhu7Xiaohui Wang8Xiaohui Wang9Yingchao Liu10Yingchao Liu11Junhong Ai12Junhong Ai13Qianyu Feng14Qianyu Feng15Li Deng16Yun Sun17Changchong Li18Rong Jin19Yunxiao Shang20Hengmiao Gao21Hengmiao Gao22Suyun Qian23Suyun Qian24Lili Xu25Lili Xu26Zhengde Xie27Zhengde Xie28Beijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Respiration, Guangzhou Women and Children’s Medical Center, Guangzhou, ChinaDepartment of Pediatrics, Yinchuan Women and Children Healthcare Hospital, Yinchuan, ChinaDepartment of Pediatric Respiratory Medicine and Sleep Medicine, The Second Afliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pediatrics, Guiyang Maternal and Child Health Hospital, Guiyang, ChinaDepartment of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaDepartment of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), Beijing Paediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaResearch Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing, ChinaWU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detected in their nasopharyngeal swabs. Furthermore, we conducted a multicentre study in six hospitals from different districts of China. WUPyV was detected by real-time polymerase chain reaction assays, and the clinical and molecular epidemiological characteristics of WUPyV strains among hospitalized children with acute lower respiratory tract infections all around China from 2017 to 2019 were analysed. Two complete WUPyV genome sequences were assembled from fatal patients’ airway specimens. Phylogenetic tree analysis revealed that they were most closely related to strains derived from Fujian and Chongqing, China, in 2008 and 2013, respectively. In 2017–2019, a total of 1,812 samples from children with acute lower respiratory tract infections were detected for WUPyV, of which 11 (0.6%) were positive. Children aged ≤5 were more susceptible to WUPyV infection. A total of 81.8% of WUPyV-positive patients were coinfected with other viruses, of which rhinovirus enjoyed the highest frequency. The main clinical symptoms of infected patients include fever, coughing and sputum expectoration. Most patients were diagnosed with pneumonia, followed by bronchial surgery. Three patients manifested severe infection, and all patients improved and were discharged. Our results show that WUPyV persistently circulates in China. Further investigations on the clinical role and pathogenicity of WUPyV are necessary.https://www.frontiersin.org/articles/10.3389/fcimb.2021.835946/fullWU polyomavirusacute lower respiratory tract infectionfatal casemulticentre studyepidemiological survey |
| spellingShingle | Hongwei Zhao Hongwei Zhao Wenmiao Xu Wenmiao Xu Lijuan Wang Lijuan Wang Yun Zhu Yun Zhu Xiaohui Wang Xiaohui Wang Yingchao Liu Yingchao Liu Junhong Ai Junhong Ai Qianyu Feng Qianyu Feng Li Deng Yun Sun Changchong Li Rong Jin Yunxiao Shang Hengmiao Gao Hengmiao Gao Suyun Qian Suyun Qian Lili Xu Lili Xu Zhengde Xie Zhengde Xie WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey Frontiers in Cellular and Infection Microbiology WU polyomavirus acute lower respiratory tract infection fatal case multicentre study epidemiological survey |
| title | WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey |
| title_full | WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey |
| title_fullStr | WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey |
| title_full_unstemmed | WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey |
| title_short | WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey |
| title_sort | wu polyomavirus infection in children with acute lower respiratory tract infections in china 2017 to 2019 case reports and multicentre epidemiological survey |
| topic | WU polyomavirus acute lower respiratory tract infection fatal case multicentre study epidemiological survey |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.835946/full |
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