Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort
Introduction: Even adolescents have early signs of periodontitis, an infectious inflammatory disease. Young patients at risk must be identified for the preventive interventions and treatment at enough early. Aim: To find out whether participants at risk for subclinical periodontitis could be identif...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13467/43031_PD(V-2_PoG_KM)_CE[Ra1]_F(SHU)_PF1(AkA_OM)_PFA(KM)_PB(AkA_OM)_PN(SL).pdf |
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| author | Teija Raivisto Timo Sorsa Ismo T Räisänen Timo Kauppila Hellevi Ruokonen Taina Tervahartiala Jari Haukka Anna Maria Heikkinen |
| author_facet | Teija Raivisto Timo Sorsa Ismo T Räisänen Timo Kauppila Hellevi Ruokonen Taina Tervahartiala Jari Haukka Anna Maria Heikkinen |
| author_sort | Teija Raivisto |
| collection | DOAJ |
| description | Introduction: Even adolescents have early signs of periodontitis, an infectious inflammatory disease. Young patients at risk must be identified for the preventive interventions and treatment at enough early. Aim: To find out whether participants at risk for subclinical periodontitis could be identified using an active Matrix Metalloproteinase-8 (aMMP-8) chairside mouth rinse test, and to study if health behaviour and oral health are linked to the test result in Finnish adolescents. Materials and Methods: This study was carried out at the Hämeenlinna Health Center in South Finland in 2017-2018. Altogether 125 participants gave their consent to the study. Adolescents (14-15-year-old) were randomly divided into the control group (n=55) and the test group (n=70). All participants of oral health was examined, and they filled a questionnaire. The aMMP-8 chairside mouth rinse test was performed for the test group. Test positives were followed four monthly for a year. Data analysis was performed by IBM SPSS Statistics Version 25 by different statistical tests, including the Mann Whitney U test, the Friedman’s test, the Dunn-Bonferroni test and the Wilcoxon test. Results: Visible Plaque Index Percentage (VPI%) was significantly higher in test positives (p=0.005). Bleeding On Probing Percentage (BOP%) reached almost statistically significant difference (p=0.052). Periodontal treatment intervention decreased aMMP-8 levels assessed by a change in the test stick result from positive (+) to negative (-) during follow-up time. Conclusion: The aMMP-8 chairside mouth rinse test identified and alarmed adolescents with poor oral hygiene at risk for subclinical periodontitis without detectable and visible manifestations of the illness, such as deepened periodontal pockets. The aMMP-8 test is fast, inexpensive, predictive, easy to use and follow the effectiveness of intervention of subclinical periodontitis. |
| first_indexed | 2024-12-11T16:54:50Z |
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| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T16:54:50Z |
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| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-a2d77bbe5c6c4cec8f45fb49bb3cc1ec2022-12-22T00:58:00ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-01-01141ZC35ZC3910.7860/JCDR/2020/43031.13467Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent CohortTeija Raivisto0Timo Sorsa1 Ismo T Räisänen2Timo Kauppila3Hellevi Ruokonen4Taina Tervahartiala5Jari Haukka6Anna Maria Heikkinen7DDS, PhD Student, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; and and Hämeenlinna Health Center, Hämeenlinna, Finland.Professor, Department of Oral and Maxillofacial Diseases and Department of Oral Diseases (Visiting Professor), University of Helsinki and Helsinki University Hospital and Karolinska Karolinska Institutet (Visiting Professor), Stockholm, Sweden.PhD student, MSc (Tech.), Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.MD, Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.DDS, PhD, MSc, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.DDS, PhD, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.Professor, Faculty of Medicine and Health Technology and Department of Public Health, Clinicum, University of Tampere and University of Helsinki, Helsinki and Tampere, Finland.DDS, PhD, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.Introduction: Even adolescents have early signs of periodontitis, an infectious inflammatory disease. Young patients at risk must be identified for the preventive interventions and treatment at enough early. Aim: To find out whether participants at risk for subclinical periodontitis could be identified using an active Matrix Metalloproteinase-8 (aMMP-8) chairside mouth rinse test, and to study if health behaviour and oral health are linked to the test result in Finnish adolescents. Materials and Methods: This study was carried out at the Hämeenlinna Health Center in South Finland in 2017-2018. Altogether 125 participants gave their consent to the study. Adolescents (14-15-year-old) were randomly divided into the control group (n=55) and the test group (n=70). All participants of oral health was examined, and they filled a questionnaire. The aMMP-8 chairside mouth rinse test was performed for the test group. Test positives were followed four monthly for a year. Data analysis was performed by IBM SPSS Statistics Version 25 by different statistical tests, including the Mann Whitney U test, the Friedman’s test, the Dunn-Bonferroni test and the Wilcoxon test. Results: Visible Plaque Index Percentage (VPI%) was significantly higher in test positives (p=0.005). Bleeding On Probing Percentage (BOP%) reached almost statistically significant difference (p=0.052). Periodontal treatment intervention decreased aMMP-8 levels assessed by a change in the test stick result from positive (+) to negative (-) during follow-up time. Conclusion: The aMMP-8 chairside mouth rinse test identified and alarmed adolescents with poor oral hygiene at risk for subclinical periodontitis without detectable and visible manifestations of the illness, such as deepened periodontal pockets. The aMMP-8 test is fast, inexpensive, predictive, easy to use and follow the effectiveness of intervention of subclinical periodontitis.https://jcdr.net/articles/PDF/13467/43031_PD(V-2_PoG_KM)_CE[Ra1]_F(SHU)_PF1(AkA_OM)_PFA(KM)_PB(AkA_OM)_PN(SL).pdfmouth washesperiodontal diseasesproteolytic enzymesteenagers |
| spellingShingle | Teija Raivisto Timo Sorsa Ismo T Räisänen Timo Kauppila Hellevi Ruokonen Taina Tervahartiala Jari Haukka Anna Maria Heikkinen Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort Journal of Clinical and Diagnostic Research mouth washes periodontal diseases proteolytic enzymes teenagers |
| title | Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort |
| title_full | Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort |
| title_fullStr | Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort |
| title_full_unstemmed | Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort |
| title_short | Active Matrix Metalloproteinase-8 Chair Side Mouth Rinse Test, Health Behaviour and Oral Health in Finnish Adolescent Cohort |
| title_sort | active matrix metalloproteinase 8 chair side mouth rinse test health behaviour and oral health in finnish adolescent cohort |
| topic | mouth washes periodontal diseases proteolytic enzymes teenagers |
| url | https://jcdr.net/articles/PDF/13467/43031_PD(V-2_PoG_KM)_CE[Ra1]_F(SHU)_PF1(AkA_OM)_PFA(KM)_PB(AkA_OM)_PN(SL).pdf |
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