Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management
Abstract Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better e...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-08-01
|
| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-018-2638-7 |
| _version_ | 1797711391197495296 |
|---|---|
| author | Khwaja Salahuddin Siddiqi Azamal Husen Sayed Sartaj Sohrab Mensur Osman Yassin |
| author_facet | Khwaja Salahuddin Siddiqi Azamal Husen Sayed Sartaj Sohrab Mensur Osman Yassin |
| author_sort | Khwaja Salahuddin Siddiqi |
| collection | DOAJ |
| description | Abstract Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better efficacy and safety to deliver specific molecules into targeted cells as compared to conventional system for neurological disorders. Depending on their properties, various metal chelators, gold nanoparticles (NPs), micelles, quantum dots, polymeric NPs, liposomes, solid lipid NPs, microparticles, carbon nanotubes, and fullerenes have been utilized for various purposes including the improvement of drug delivery system, treatment response assessment, diagnosis at early stage, and management of neurological disorder by using neuro-engineering. BBB regulates micro- and macromolecule penetration/movement, thus protecting it from many kinds of illness. This phenomenon also prevents drug delivery for the neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and primary brain tumors. For some neurological disorders (AD and PD), the environmental pollution was considered as a major cause, as observed that metal and/or metal oxide from different sources are inhaled and get deposited in the lungs/brain. Old age, obesity, diabetes, and cardiovascular disease are other factors for rapid deterioration of human health and onset of AD. In addition, gene mutations have also been examined to cause the early onset familial forms of AD. AD leads to cognitive impairment and plaque deposits in the brain leading to neuronal cell death. Based on these facts and considerations, this review elucidates the importance of frequently used metal chelators, NMs and/or NPs. The present review also discusses the current status and future challenges in terms of their application in drug delivery for neurological disease management. |
| first_indexed | 2024-03-12T07:06:24Z |
| format | Article |
| id | doaj.art-a2d7a68ba61843d4b1fa024e190a9489 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T07:06:24Z |
| publishDate | 2018-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-a2d7a68ba61843d4b1fa024e190a94892023-09-02T23:24:37ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2018-08-0113111710.1186/s11671-018-2638-7Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease ManagementKhwaja Salahuddin Siddiqi0Azamal Husen1Sayed Sartaj Sohrab2Mensur Osman Yassin3Department of Chemistry, Aligarh Muslim UniversityDepartment of Biology, College of Natural and Computational Sciences, University of GondarSpecial Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz UniversityDepartment of Surgery, College of Medicine and Health Sciences, University of GondarAbstract Nanomaterials (NMs) are receiving remarkable attention due to their unique properties and structure. They vary from atoms and molecules along with those of bulk materials. They can be engineered to act as drug delivery vehicles to cross blood-brain barriers (BBBs) and utilized with better efficacy and safety to deliver specific molecules into targeted cells as compared to conventional system for neurological disorders. Depending on their properties, various metal chelators, gold nanoparticles (NPs), micelles, quantum dots, polymeric NPs, liposomes, solid lipid NPs, microparticles, carbon nanotubes, and fullerenes have been utilized for various purposes including the improvement of drug delivery system, treatment response assessment, diagnosis at early stage, and management of neurological disorder by using neuro-engineering. BBB regulates micro- and macromolecule penetration/movement, thus protecting it from many kinds of illness. This phenomenon also prevents drug delivery for the neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and primary brain tumors. For some neurological disorders (AD and PD), the environmental pollution was considered as a major cause, as observed that metal and/or metal oxide from different sources are inhaled and get deposited in the lungs/brain. Old age, obesity, diabetes, and cardiovascular disease are other factors for rapid deterioration of human health and onset of AD. In addition, gene mutations have also been examined to cause the early onset familial forms of AD. AD leads to cognitive impairment and plaque deposits in the brain leading to neuronal cell death. Based on these facts and considerations, this review elucidates the importance of frequently used metal chelators, NMs and/or NPs. The present review also discusses the current status and future challenges in terms of their application in drug delivery for neurological disease management.http://link.springer.com/article/10.1186/s11671-018-2638-7Nanomaterials/nanoparticlesNanomedicinesBiomedical applicationDrug deliveryHealth and safety |
| spellingShingle | Khwaja Salahuddin Siddiqi Azamal Husen Sayed Sartaj Sohrab Mensur Osman Yassin Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management Nanoscale Research Letters Nanomaterials/nanoparticles Nanomedicines Biomedical application Drug delivery Health and safety |
| title | Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management |
| title_full | Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management |
| title_fullStr | Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management |
| title_full_unstemmed | Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management |
| title_short | Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management |
| title_sort | recent status of nanomaterial fabrication and their potential applications in neurological disease management |
| topic | Nanomaterials/nanoparticles Nanomedicines Biomedical application Drug delivery Health and safety |
| url | http://link.springer.com/article/10.1186/s11671-018-2638-7 |
| work_keys_str_mv | AT khwajasalahuddinsiddiqi recentstatusofnanomaterialfabricationandtheirpotentialapplicationsinneurologicaldiseasemanagement AT azamalhusen recentstatusofnanomaterialfabricationandtheirpotentialapplicationsinneurologicaldiseasemanagement AT sayedsartajsohrab recentstatusofnanomaterialfabricationandtheirpotentialapplicationsinneurologicaldiseasemanagement AT mensurosmanyassin recentstatusofnanomaterialfabricationandtheirpotentialapplicationsinneurologicaldiseasemanagement |