Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study
Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/5/896 |
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| author | Anthia Papazoglou Anna Conen Sebastian Haubitz Markus Tschopp Viviane J. Guignard Marcel N. Menke Tim J. Enz |
| author_facet | Anthia Papazoglou Anna Conen Sebastian Haubitz Markus Tschopp Viviane J. Guignard Marcel N. Menke Tim J. Enz |
| author_sort | Anthia Papazoglou |
| collection | DOAJ |
| description | Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29–90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0–1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8–22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue. |
| first_indexed | 2024-03-09T00:34:46Z |
| format | Article |
| id | doaj.art-a2d92ea6a3f84fa3943c10e32e458656 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:34:46Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a2d92ea6a3f84fa3943c10e32e4586562023-12-11T18:15:02ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110589610.3390/jcm10050896Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort StudyAnthia Papazoglou0Anna Conen1Sebastian Haubitz2Markus Tschopp3Viviane J. Guignard4Marcel N. Menke5Tim J. Enz6Department of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Infectious Diseases and Hospital Hygiene, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Infectious Diseases and Hospital Hygiene, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandDepartment of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, SwitzerlandPostmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29–90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0–1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8–22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.https://www.mdpi.com/2077-0383/10/5/896SARS-CoV-2COVID-19ocular involvementretinaoptic nerve |
| spellingShingle | Anthia Papazoglou Anna Conen Sebastian Haubitz Markus Tschopp Viviane J. Guignard Marcel N. Menke Tim J. Enz Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study Journal of Clinical Medicine SARS-CoV-2 COVID-19 ocular involvement retina optic nerve |
| title | Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study |
| title_full | Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study |
| title_fullStr | Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study |
| title_full_unstemmed | Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study |
| title_short | Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study |
| title_sort | ophthalmic screening in patients with coronavirus disease 2019 a prospective cohort study |
| topic | SARS-CoV-2 COVID-19 ocular involvement retina optic nerve |
| url | https://www.mdpi.com/2077-0383/10/5/896 |
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