Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study
Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/16/3404 |
| _version_ | 1797408518599344128 |
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| author | Kristin M. Davis Kristina S. Petersen Kate J. Bowen Peter J. H. Jones Carla G. Taylor Peter Zahradka Karen Letourneau Danielle Perera Angela Wilson Paul R. Wagner Penny M. Kris-Etherton Sheila G. West |
| author_facet | Kristin M. Davis Kristina S. Petersen Kate J. Bowen Peter J. H. Jones Carla G. Taylor Peter Zahradka Karen Letourneau Danielle Perera Angela Wilson Paul R. Wagner Penny M. Kris-Etherton Sheila G. West |
| author_sort | Kristin M. Davis |
| collection | DOAJ |
| description | Partial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (<i>n</i> = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; <i>p</i> = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; <i>p</i> = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; <i>p</i> = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome. |
| first_indexed | 2024-03-09T04:00:39Z |
| format | Article |
| id | doaj.art-a2da57b9f64e4c258c37f20fe0fe0a16 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T04:00:39Z |
| publishDate | 2022-08-01 |
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| series | Nutrients |
| spelling | doaj.art-a2da57b9f64e4c258c37f20fe0fe0a162023-12-03T14:14:52ZengMDPI AGNutrients2072-66432022-08-011416340410.3390/nu14163404Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding StudyKristin M. Davis0Kristina S. Petersen1Kate J. Bowen2Peter J. H. Jones3Carla G. Taylor4Peter Zahradka5Karen Letourneau6Danielle Perera7Angela Wilson8Paul R. Wagner9Penny M. Kris-Etherton10Sheila G. West11Department of Biobehavioral Health, Pennsylvania State University, State College, PA 16802, USADepartment of Nutritional Sciences, Pennsylvania State University, State College, PA 16802, USADepartment of Nutritional Sciences, Pennsylvania State University, State College, PA 16802, USARichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, CanadaDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaThe Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital, Winnipeg, MB R2H 2A6, CanadaThe Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital, Winnipeg, MB R2H 2A6, CanadaThe Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital, Winnipeg, MB R2H 2A6, CanadaDepartment of Biobehavioral Health, Pennsylvania State University, State College, PA 16802, USADepartment of Nutritional Sciences, Pennsylvania State University, State College, PA 16802, USADepartment of Biobehavioral Health, Pennsylvania State University, State College, PA 16802, USAPartial replacement of saturated fatty acids (SFA) with unsaturated fatty acids is recommended to reduce cardiovascular disease (CVD) risk. Monounsaturated fatty acids (MUFA), including oleic acid, are associated with lower CVD risk. Measurement of flow-mediated dilation of the brachial artery (FMD) is the gold standard for measuring endothelial function and predicts CVD risk. This study examined the effect of partially replacing SFA with MUFA from conventional canola oil and high-oleic acid canola oil on FMD. Participants (<i>n</i> = 31) with an elevated waist circumference plus ≥1 additional metabolic syndrome criterion completed FMD measures as part of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a multi-center, double-blind, three-period crossover, controlled feeding randomized trial. Diet periods were 6 weeks, separated by ≥4-week washouts. Experimental diets were provided during all feeding periods. Diets only differed by the fatty acid profile of the oils: canola oil (CO; 17.5% energy from MUFA, 9.2% polyunsaturated fatty acids (PUFA), 6.6% SFA), high-oleic acid canola oil (HOCO; 19.1% MUFA, 7.0% PUFA, 6.4% SFA), and a control oil blend (CON; 11% MUFA, 10% PUFA, 12% SFA). Multilevel models were used to examine the effect of the diets on FMD. No significant between-diet differences were observed for average brachial artery diameter (CO: 6.70 ± 0.15 mm, HOCO: 6.57 ± 0.15 mm, CON: 6.73 ± 0.14 mm; <i>p</i> = 0.72), peak brachial artery diameter (CO: 7.11 ± 0.15 mm, HOCO: 7.02 ± 0.15 mm, CON: 6.41 ± 0.48 mm; <i>p</i> = 0.80), or FMD (CO: 6.32 ± 0.51%, HOCO: 6.96 ± 0.49%, CON: 6.41 ± 0.48%; <i>p</i> = 0.81). Partial replacement of SFA with MUFA from CO and HOCO had no effect on FMD in participants with or at risk of metabolic syndrome.https://www.mdpi.com/2072-6643/14/16/3404flow-mediated dilationconventional canola oilhigh-oleic canola oilcardiovascular disease risk |
| spellingShingle | Kristin M. Davis Kristina S. Petersen Kate J. Bowen Peter J. H. Jones Carla G. Taylor Peter Zahradka Karen Letourneau Danielle Perera Angela Wilson Paul R. Wagner Penny M. Kris-Etherton Sheila G. West Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study Nutrients flow-mediated dilation conventional canola oil high-oleic canola oil cardiovascular disease risk |
| title | Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study |
| title_full | Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study |
| title_fullStr | Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study |
| title_full_unstemmed | Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study |
| title_short | Effects of Diets Enriched with Conventional or High-Oleic Canola Oils on Vascular Endothelial Function: A Sub-Study of the Canola Oil Multi-Centre Intervention Trial 2 (COMIT-2), a Randomized Crossover Controlled Feeding Study |
| title_sort | effects of diets enriched with conventional or high oleic canola oils on vascular endothelial function a sub study of the canola oil multi centre intervention trial 2 comit 2 a randomized crossover controlled feeding study |
| topic | flow-mediated dilation conventional canola oil high-oleic canola oil cardiovascular disease risk |
| url | https://www.mdpi.com/2072-6643/14/16/3404 |
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