Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling

Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling

Mycobacterium bovis is the causative agent of bovine tuberculosis, has been identified a serious threat to human population. It has been found that sodium butyrate (NaB), the inhibitor of histone deacetylase, can promote the expression of cathelicidin (LL37) and help the body to resist a variety of...

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Bibliographic Details
Main Authors: Kai Zhang, Tariq Hussain, Jie Wang, Mengying Li, Wenjia Wang, Xiaojing Ma, Yi Liao, Jiao Yao, Yinjuan Song, Zhengmin Liang, Xiangmei Zhou, Lihua Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium bovis
sodium butyrate
histone deacetylation
Nuclear factor-κB
cathelicidin
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00433/full

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