Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. Here, we made a series of UBR5 HECT domain truncation variants and, through pull-down assay, showed that the N-termina...

Full description

Bibliographic Details
Main Authors: Qingya Shen, Zhiyu Qiu, Wenping Wu, Jimin Zheng, Zongchao Jia
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Biology Open
Subjects:
PEPCK1
E3 ligase
Ubiquitination
HECT N-lobe
Acetylation
Online Access:http://bio.biologists.org/content/7/12/bio037366

Similar Items

Similar Items