Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy
There is a need to personalize the treatment for rectal cancer patients. The aim of this study was to analyze therapy response and prognosis after preoperative radiotherapy in rectal cancer patients with mucinous adenocarcinoma compared to those with non-mucinous adenocarcinoma. The study included r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/10/4/226 |
| _version_ | 1797547996473196544 |
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| author | Karolina Vernmark Xiao-Feng Sun Annica Holmqvist |
| author_facet | Karolina Vernmark Xiao-Feng Sun Annica Holmqvist |
| author_sort | Karolina Vernmark |
| collection | DOAJ |
| description | There is a need to personalize the treatment for rectal cancer patients. The aim of this study was to analyze therapy response and prognosis after preoperative radiotherapy in rectal cancer patients with mucinous adenocarcinoma compared to those with non-mucinous adenocarcinoma. The study included retrospectively collected data from 433 patients, diagnosed with rectal cancer in the South East health care region in Sweden between 2004 and 2012. Patients with non-mucinous adenocarcinoma that received short-course radiotherapy before surgery had better overall survival, cancer specific survival, and disease-free survival, as well as distant- and local-recurrence-free survival (<i>p</i> = 0.003, <i>p</i> = 0.001, <i>p</i> = 0.002, <i>p</i> = 0.002, and <i>p</i> = 0.033, respectively) compared to the patients that received long-course radiotherapy with concomitant capecitabine. The results were still significant after adjusting for sex, age, stage, differentiation, and chemotherapy in the neoadjuvant and/or adjuvant setting, except for local-recurrence-free survival that was trending towards significance (<i>p</i> = 0.070). In patients with mucinous adenocarcinoma, no difference in survival was seen when comparing patients that had short-course radiotherapy and patients that had long-course radiotherapy. However, none of 18 patients with mucinous adenocarcinoma treated with long-course radiotherapy had local tumor progression, compared to 7% of 67 patients with non-mucinous adenocarcinoma. The results indicate that mucinous adenocarcinoma and non-mucinous adenocarcinoma may respond differently to radiotherapy. |
| first_indexed | 2024-03-10T14:53:04Z |
| format | Article |
| id | doaj.art-a2df35d1703349ca9f041a36bc2ab624 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T14:53:04Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-a2df35d1703349ca9f041a36bc2ab6242023-11-20T20:49:59ZengMDPI AGJournal of Personalized Medicine2075-44262020-11-0110422610.3390/jpm10040226Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative RadiotherapyKarolina Vernmark0Xiao-Feng Sun1Annica Holmqvist2Department of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, SwedenDepartment of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, SwedenDepartment of Biomedical and Clinical Sciences, Linköping University, 58183 Linköping, SwedenThere is a need to personalize the treatment for rectal cancer patients. The aim of this study was to analyze therapy response and prognosis after preoperative radiotherapy in rectal cancer patients with mucinous adenocarcinoma compared to those with non-mucinous adenocarcinoma. The study included retrospectively collected data from 433 patients, diagnosed with rectal cancer in the South East health care region in Sweden between 2004 and 2012. Patients with non-mucinous adenocarcinoma that received short-course radiotherapy before surgery had better overall survival, cancer specific survival, and disease-free survival, as well as distant- and local-recurrence-free survival (<i>p</i> = 0.003, <i>p</i> = 0.001, <i>p</i> = 0.002, <i>p</i> = 0.002, and <i>p</i> = 0.033, respectively) compared to the patients that received long-course radiotherapy with concomitant capecitabine. The results were still significant after adjusting for sex, age, stage, differentiation, and chemotherapy in the neoadjuvant and/or adjuvant setting, except for local-recurrence-free survival that was trending towards significance (<i>p</i> = 0.070). In patients with mucinous adenocarcinoma, no difference in survival was seen when comparing patients that had short-course radiotherapy and patients that had long-course radiotherapy. However, none of 18 patients with mucinous adenocarcinoma treated with long-course radiotherapy had local tumor progression, compared to 7% of 67 patients with non-mucinous adenocarcinoma. The results indicate that mucinous adenocarcinoma and non-mucinous adenocarcinoma may respond differently to radiotherapy.https://www.mdpi.com/2075-4426/10/4/226mucinous adenocarcinomanon-mucinous adenocarcinomaradiotherapyrectal cancersurvival |
| spellingShingle | Karolina Vernmark Xiao-Feng Sun Annica Holmqvist Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy Journal of Personalized Medicine mucinous adenocarcinoma non-mucinous adenocarcinoma radiotherapy rectal cancer survival |
| title | Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy |
| title_full | Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy |
| title_fullStr | Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy |
| title_full_unstemmed | Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy |
| title_short | Mucinous and Non-Mucinous Rectal Adenocarcinoma—Differences in Treatment Response to Preoperative Radiotherapy |
| title_sort | mucinous and non mucinous rectal adenocarcinoma differences in treatment response to preoperative radiotherapy |
| topic | mucinous adenocarcinoma non-mucinous adenocarcinoma radiotherapy rectal cancer survival |
| url | https://www.mdpi.com/2075-4426/10/4/226 |
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