Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs study
Introduction Nicotine-containing products (NCPs) such as electronic nicotine delivery systems (ENDS) are increasingly common throughout the landscape of youth use of nicotine-containing products (NCP), and have overtaken traditional cigarette smoking modalities. This study seeks to examine the genet...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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European Publishing
2023-11-01
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| Series: | Tobacco Prevention and Cessation |
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| Online Access: | https://www.tobaccopreventioncessation.com/Genetic-and-environmental-influences-on-early-age-nsusceptibility-and-initiation,173556,0,2.html |
| _version_ | 1797338172508602368 |
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| author | Andrew Kochvar Yadi Liu Marcus Munafo Zheng Xu Hongying Dai |
| author_facet | Andrew Kochvar Yadi Liu Marcus Munafo Zheng Xu Hongying Dai |
| author_sort | Andrew Kochvar |
| collection | DOAJ |
| description | Introduction
Nicotine-containing products (NCPs) such as electronic nicotine
delivery systems (ENDS) are increasingly common throughout the landscape of
youth use of nicotine-containing products (NCP), and have overtaken traditional
cigarette smoking modalities. This study seeks to examine the genetic and
environmental influences on liability for susceptibility and initiation of ENDS
and other NCPs among US children.
Methods
Data were drawn from 886 monozygotic (MZ) and dizygotic (DZ) twin
pairs aged 9–10 years in the Adolescent Brain & Cognitive Development (ABCD)
study at the baseline during 2016–2018. Heritability (h2) measured the proportion
of the total phenotypic variation attributable to genes. Variance component models
were utilized to analyze influences from the common environment (c2) and unique
environmental factors (e2), taking into account correlations within twin pairs.
Results
The national sample included 50% females, 69.5% of non-Hispanic Whites,
12.8% of non-Hispanic Blacks, and 11.6% of Hispanics, with a mean age of
121.5 months. The twin sets were 60% DZ and 40% MZ. Heritability was low for
NCP susceptibility (h2=0) and moderate for NCP initiation (h2=39%, p=0.02).
The variance associated with NCP susceptibility was primarily influenced by
environmental factors, especially one’s unique factors (c2=37%, p<0.0001 vs
e2=63%, p<0.0001). In contrast, the variance associated with NCP initiation was
split across common and unique environmental factors (c2=32%, p=0.02 vs e2=29%,
p=0.02).
Conclusions
In the era with ENDS use surging among youth, NCP initiation remains
to be a heritable trait with joint influence from the environment. NCP susceptibility
is largely influenced by environmental factors, especially unique environments.
Continued assessment of gene × environment interaction can better inform future
youth NCP interventions. |
| first_indexed | 2024-03-08T09:26:11Z |
| format | Article |
| id | doaj.art-a2e03f14e6b540f2902a865c8b486f30 |
| institution | Directory Open Access Journal |
| issn | 2459-3087 |
| language | English |
| last_indexed | 2024-03-08T09:26:11Z |
| publishDate | 2023-11-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Prevention and Cessation |
| spelling | doaj.art-a2e03f14e6b540f2902a865c8b486f302024-01-31T09:05:05ZengEuropean PublishingTobacco Prevention and Cessation2459-30872023-11-019November1910.18332/tpc/173556173556Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs studyAndrew Kochvar0Yadi Liu1Marcus Munafo2Zheng Xu3Hongying Dai4https://orcid.org/0000-0003-1395-7904College of Public Health, University of Nebraska Medical Center, Omaha, United StatesCollege of Public Health, University of Nebraska Medical Center, Omaha, United StatesBristol Population Health Science Institute, University of Bristol, Bristol, United KingdomDepartment of Mathematics and Statistics, Wright State University, Dayton, United StatesCollege of Public Health, University of Nebraska Medical Center, Omaha, United StatesIntroduction Nicotine-containing products (NCPs) such as electronic nicotine delivery systems (ENDS) are increasingly common throughout the landscape of youth use of nicotine-containing products (NCP), and have overtaken traditional cigarette smoking modalities. This study seeks to examine the genetic and environmental influences on liability for susceptibility and initiation of ENDS and other NCPs among US children. Methods Data were drawn from 886 monozygotic (MZ) and dizygotic (DZ) twin pairs aged 9–10 years in the Adolescent Brain & Cognitive Development (ABCD) study at the baseline during 2016–2018. Heritability (h2) measured the proportion of the total phenotypic variation attributable to genes. Variance component models were utilized to analyze influences from the common environment (c2) and unique environmental factors (e2), taking into account correlations within twin pairs. Results The national sample included 50% females, 69.5% of non-Hispanic Whites, 12.8% of non-Hispanic Blacks, and 11.6% of Hispanics, with a mean age of 121.5 months. The twin sets were 60% DZ and 40% MZ. Heritability was low for NCP susceptibility (h2=0) and moderate for NCP initiation (h2=39%, p=0.02). The variance associated with NCP susceptibility was primarily influenced by environmental factors, especially one’s unique factors (c2=37%, p<0.0001 vs e2=63%, p<0.0001). In contrast, the variance associated with NCP initiation was split across common and unique environmental factors (c2=32%, p=0.02 vs e2=29%, p=0.02). Conclusions In the era with ENDS use surging among youth, NCP initiation remains to be a heritable trait with joint influence from the environment. NCP susceptibility is largely influenced by environmental factors, especially unique environments. Continued assessment of gene × environment interaction can better inform future youth NCP interventions.https://www.tobaccopreventioncessation.com/Genetic-and-environmental-influences-on-early-age-nsusceptibility-and-initiation,173556,0,2.htmlnicotine-containing product useinitiationnicotine-containingproduct use susceptibilityheritabilitygenetic factorsenvironmental factorsabcdstudy |
| spellingShingle | Andrew Kochvar Yadi Liu Marcus Munafo Zheng Xu Hongying Dai Genetic and environmental influences on early-age susceptibility and initiation of nicotine-containing product use: A twin-pairs study Tobacco Prevention and Cessation nicotine-containing product use initiation nicotine-containing product use susceptibility heritability genetic factors environmental factors abcd study |
| title | Genetic and environmental influences on early-age
susceptibility and initiation of nicotine-containing product
use: A twin-pairs study |
| title_full | Genetic and environmental influences on early-age
susceptibility and initiation of nicotine-containing product
use: A twin-pairs study |
| title_fullStr | Genetic and environmental influences on early-age
susceptibility and initiation of nicotine-containing product
use: A twin-pairs study |
| title_full_unstemmed | Genetic and environmental influences on early-age
susceptibility and initiation of nicotine-containing product
use: A twin-pairs study |
| title_short | Genetic and environmental influences on early-age
susceptibility and initiation of nicotine-containing product
use: A twin-pairs study |
| title_sort | genetic and environmental influences on early age susceptibility and initiation of nicotine containing product use a twin pairs study |
| topic | nicotine-containing product use initiation nicotine-containing product use susceptibility heritability genetic factors environmental factors abcd study |
| url | https://www.tobaccopreventioncessation.com/Genetic-and-environmental-influences-on-early-age-nsusceptibility-and-initiation,173556,0,2.html |
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