Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat
A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non‐human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac my...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.14663 |
| _version_ | 1811237832070529024 |
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| author | M.D. Kittleson P.R. Fox C. Basso G. Thiene |
| author_facet | M.D. Kittleson P.R. Fox C. Basso G. Thiene |
| author_sort | M.D. Kittleson |
| collection | DOAJ |
| description | A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non‐human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth‐eaten appearance to the inner wall of the mid‐ to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial‐lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased. |
| first_indexed | 2024-04-12T12:30:00Z |
| format | Article |
| id | doaj.art-a2e13780129d41f8a3a8f70446cb4a4e |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T12:30:00Z |
| publishDate | 2017-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-a2e13780129d41f8a3a8f70446cb4a4e2022-12-22T03:33:03ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762017-03-0131252753110.1111/jvim.14663Naturally Occurring Biventricular Noncompaction in an Adult Domestic CatM.D. Kittleson0P.R. Fox1C. Basso2G. Thiene3Department of Medicine & Epidemiology School of Veterinary Medicine University of California Davis CAAnimal Medical Center New York NYDepartment of Cardiac, Thoracic and Vascular Sciences University of Padua Medical School Padova ItalyDepartment of Cardiac, Thoracic and Vascular Sciences University of Padua Medical School Padova ItalyA definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non‐human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth‐eaten appearance to the inner wall of the mid‐ to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial‐lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.https://doi.org/10.1111/jvim.14663CardiomyopathyEchocardiographyFelineHypertrabeculationLeft VentricleNoncompaction |
| spellingShingle | M.D. Kittleson P.R. Fox C. Basso G. Thiene Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat Journal of Veterinary Internal Medicine Cardiomyopathy Echocardiography Feline Hypertrabeculation Left Ventricle Noncompaction |
| title | Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat |
| title_full | Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat |
| title_fullStr | Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat |
| title_full_unstemmed | Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat |
| title_short | Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat |
| title_sort | naturally occurring biventricular noncompaction in an adult domestic cat |
| topic | Cardiomyopathy Echocardiography Feline Hypertrabeculation Left Ventricle Noncompaction |
| url | https://doi.org/10.1111/jvim.14663 |
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