Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study)
Intake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized con...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Contemporary Clinical Trials Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865419300018 |
| _version_ | 1818959631627583488 |
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| author | Bernadette P. Marriott Travis H. Turner Joseph R. Hibbeln Marcie Pregulman Jill Newman Kristen B. Johnson Angela M. Malek Robert J. Malcolm Gregory A. Burbelo Jeffrey W. Wissman Lindsay S. Nicholas Carlyn J. Taylor Anja M. Velez Landivar Anita D. Deveaux Rebecca A. Atkinson Ashlea L. Sikon Jacqueline S. Ross |
| author_facet | Bernadette P. Marriott Travis H. Turner Joseph R. Hibbeln Marcie Pregulman Jill Newman Kristen B. Johnson Angela M. Malek Robert J. Malcolm Gregory A. Burbelo Jeffrey W. Wissman Lindsay S. Nicholas Carlyn J. Taylor Anja M. Velez Landivar Anita D. Deveaux Rebecca A. Atkinson Ashlea L. Sikon Jacqueline S. Ross |
| author_sort | Bernadette P. Marriott |
| collection | DOAJ |
| description | Intake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized controlled trials. Omega-3 (HUFAs), specifically EPA (eicosapentaenoic acid) and docosahexaenoic acid (DHA), are concentrated in neural tissues and are essential for neural function, normative neurodevelopment, neurotransmitter, and neural immune functions. Omega-3 HUFAs must be obtained from the diet, predominantly from marine sources such as fish and other seafood. HUFAs also can be found in a variety of dietary supplements (omega-3 fatty acid esters, fish oil and krill oil). As dietary supplements, omega-3 HUFAs (fatty acid esters, fish and krill oils) differ substantially in their physicochemical properties and nutrient content. Here we present the design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3) study. RRIPP-3 was a double blind, randomized, controlled trial among individuals in the United States (US) Army Infantry Basic Officer Leaders Course (IBOLC) and following US Ranger School training (RC) at Fort Benning, GA of omega-3 HUFA on krill oil versus placebo supplementation. The RRIPP-3 study sought to determine if krill oil supplementation with omega-3 HUFAs supports aspects of cognitive functioning critical to battlefield success when measured immediately after an intense combat simulation. Sub-analyses addressed basic improvements in IBOLC performance. We also describe additional outcome measures critical for interpretation of the study results, such as diet and other dietary supplement use. Keywords: Omega-3 fatty acids, Cognition, Krill oil, US Army officers, Phospholipids, Resilience |
| first_indexed | 2024-12-20T11:44:43Z |
| format | Article |
| id | doaj.art-a2e209eb9fd5413384d9073b362d0596 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-12-20T11:44:43Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-a2e209eb9fd5413384d9073b362d05962022-12-21T19:41:53ZengElsevierContemporary Clinical Trials Communications2451-86542019-09-0115Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study)Bernadette P. Marriott0Travis H. Turner1Joseph R. Hibbeln2Marcie Pregulman3Jill Newman4Kristen B. Johnson5Angela M. Malek6Robert J. Malcolm7Gregory A. Burbelo8Jeffrey W. Wissman9Lindsay S. NicholasCarlyn J. TaylorAnja M. Velez LandivarAnita D. DeveauxRebecca A. AtkinsonAshlea L. SikonJacqueline S. RossNutrition Section, Division of Gastroenterology and Hepatology, Department of Medicine, and Military Division, Department of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Ste. 630D, MSC774, Charleston, SC, 29425, USA; Corresponding author. Emeritus Professor, Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, 114 Doughty Street, Suite 629, MSC 774, Charleston, SC, 29425-7740, USA.Department of Neurology, College of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 301 CSB, Charleston, SC, 29425, USAActing Chief, Section on Nutritional Neurosciences, LMBB, NIAAA, NIH, 5625 Fishers Lane, Rm 3N-07, MSC 9410, Bethesda, MD, 20892, USANutrition Section, Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Ste. 630D, MSC774, Charleston, SC 29425, USANutrition Section, Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Ste. 630D, MSC774, Charleston, SC 29425, USANutrition Section, Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Ste. 630D, MSC774, Charleston, SC 29425, USADepartment of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Ste. 303C, Charleston, SC, 29425, USADepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, Charleston, SC, 29425, USANorthrop Grumman Corp, 3565 Macon Rd, Columbus, GA, 31907, USAManeuver Center of Excellence, Infantry Basic Officers Leader Course, Fort Benning, GA, 31905, USAIntake of nutrients fundamental for optimal neuronal function is of increasing interest. The potential importance of omega-3 highly unsaturated fatty acids (HUFAs) for optimizing emotional states, cognitive function, and mental health has been demonstrated in observational studies and randomized controlled trials. Omega-3 (HUFAs), specifically EPA (eicosapentaenoic acid) and docosahexaenoic acid (DHA), are concentrated in neural tissues and are essential for neural function, normative neurodevelopment, neurotransmitter, and neural immune functions. Omega-3 HUFAs must be obtained from the diet, predominantly from marine sources such as fish and other seafood. HUFAs also can be found in a variety of dietary supplements (omega-3 fatty acid esters, fish oil and krill oil). As dietary supplements, omega-3 HUFAs (fatty acid esters, fish and krill oils) differ substantially in their physicochemical properties and nutrient content. Here we present the design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3) study. RRIPP-3 was a double blind, randomized, controlled trial among individuals in the United States (US) Army Infantry Basic Officer Leaders Course (IBOLC) and following US Ranger School training (RC) at Fort Benning, GA of omega-3 HUFA on krill oil versus placebo supplementation. The RRIPP-3 study sought to determine if krill oil supplementation with omega-3 HUFAs supports aspects of cognitive functioning critical to battlefield success when measured immediately after an intense combat simulation. Sub-analyses addressed basic improvements in IBOLC performance. We also describe additional outcome measures critical for interpretation of the study results, such as diet and other dietary supplement use. Keywords: Omega-3 fatty acids, Cognition, Krill oil, US Army officers, Phospholipids, Resiliencehttp://www.sciencedirect.com/science/article/pii/S2451865419300018 |
| spellingShingle | Bernadette P. Marriott Travis H. Turner Joseph R. Hibbeln Marcie Pregulman Jill Newman Kristen B. Johnson Angela M. Malek Robert J. Malcolm Gregory A. Burbelo Jeffrey W. Wissman Lindsay S. Nicholas Carlyn J. Taylor Anja M. Velez Landivar Anita D. Deveaux Rebecca A. Atkinson Ashlea L. Sikon Jacqueline S. Ross Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) Contemporary Clinical Trials Communications |
| title | Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) |
| title_full | Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) |
| title_fullStr | Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) |
| title_full_unstemmed | Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) |
| title_short | Design and methods for the Ranger Resilience and Improved Performance on Phospholipid bound Omega-3's (RRIPP-3 study) |
| title_sort | design and methods for the ranger resilience and improved performance on phospholipid bound omega 3 s rripp 3 study |
| url | http://www.sciencedirect.com/science/article/pii/S2451865419300018 |
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