Motor and histological findings in a model of sci: comparison between posterior and lateral clips
Objective: To evaluate the locomotor and histological impact on the spinal cord comparing lateral and posterior clip placement. Method: Randomized experimental trial. Twenty female Wistar rats, weighing between 250 and 300 gra...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Coluna (SBC)
2014-12-01
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| Series: | Coluna/Columna |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512014000400318&lng=en&tlng=en |
| _version_ | 1818155684069376000 |
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| author | Asdrubal Falavigna Guilherme Finger Cesar Sebben Pedro Guarise da Silva Lucas Piccoli Conzati Manuela Peletti-Figueiro |
| author_facet | Asdrubal Falavigna Guilherme Finger Cesar Sebben Pedro Guarise da Silva Lucas Piccoli Conzati Manuela Peletti-Figueiro |
| author_sort | Asdrubal Falavigna |
| collection | DOAJ |
| description | Objective: To evaluate the locomotor and histological impact on the spinal cord comparing lateral and posterior clip placement. Method: Randomized experimental trial. Twenty female Wistar rats, weighing between 250 and 300 grams and aged 12-14 weeks were randomized in two groups according to the placement of the clip: lateral group (N=10) and posterior group (N=10). After exposing the thoracic segment of the spine (T8-T10), a laminectomy was performed at the T9 level under microscopic view. The spinal cord injury was made using a 5 mm long aneurysm clip with a closing pressure of 50 grams. Locomotor behavior was evaluated by the Basso, Beattie and Bresnahan scale in days 1, 7, 14, 21, and 28 after surgery. The area of injury was assessed by histological analysis and measured by a software. Results: The histological evaluation showed a larger mean area of 4.8±1mm² of lesion (P=0.03) in the lateral group when compared with the posterior group mean area of 2.3±2mm². There was no significant difference between lateral and posterior groups with respect to locomotor scores from day 1 to 28 (P=0.361). Conclusion: The lesion area observed in the spinal cord histology after lateral placement of a clip was significantly bigger than in the posterior placement. The motor evaluation showed similar BBB scores regardless of the type of clamping method. |
| first_indexed | 2024-12-11T14:46:19Z |
| format | Article |
| id | doaj.art-a2e25e309758420596f966d34acc645f |
| institution | Directory Open Access Journal |
| issn | 2177-014X |
| language | English |
| last_indexed | 2024-12-11T14:46:19Z |
| publishDate | 2014-12-01 |
| publisher | Sociedade Brasileira de Coluna (SBC) |
| record_format | Article |
| series | Coluna/Columna |
| spelling | doaj.art-a2e25e309758420596f966d34acc645f2022-12-22T01:01:40ZengSociedade Brasileira de Coluna (SBC)Coluna/Columna2177-014X2014-12-0113431832110.1590/S1808-18512014130400474S1808-18512014000400318Motor and histological findings in a model of sci: comparison between posterior and lateral clipsAsdrubal FalavignaGuilherme FingerCesar SebbenPedro Guarise da SilvaLucas Piccoli ConzatiManuela Peletti-FigueiroObjective: To evaluate the locomotor and histological impact on the spinal cord comparing lateral and posterior clip placement. Method: Randomized experimental trial. Twenty female Wistar rats, weighing between 250 and 300 grams and aged 12-14 weeks were randomized in two groups according to the placement of the clip: lateral group (N=10) and posterior group (N=10). After exposing the thoracic segment of the spine (T8-T10), a laminectomy was performed at the T9 level under microscopic view. The spinal cord injury was made using a 5 mm long aneurysm clip with a closing pressure of 50 grams. Locomotor behavior was evaluated by the Basso, Beattie and Bresnahan scale in days 1, 7, 14, 21, and 28 after surgery. The area of injury was assessed by histological analysis and measured by a software. Results: The histological evaluation showed a larger mean area of 4.8±1mm² of lesion (P=0.03) in the lateral group when compared with the posterior group mean area of 2.3±2mm². There was no significant difference between lateral and posterior groups with respect to locomotor scores from day 1 to 28 (P=0.361). Conclusion: The lesion area observed in the spinal cord histology after lateral placement of a clip was significantly bigger than in the posterior placement. The motor evaluation showed similar BBB scores regardless of the type of clamping method.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512014000400318&lng=en&tlng=en |
| spellingShingle | Asdrubal Falavigna Guilherme Finger Cesar Sebben Pedro Guarise da Silva Lucas Piccoli Conzati Manuela Peletti-Figueiro Motor and histological findings in a model of sci: comparison between posterior and lateral clips Coluna/Columna |
| title | Motor and histological findings in a model of sci: comparison between posterior and lateral clips |
| title_full | Motor and histological findings in a model of sci: comparison between posterior and lateral clips |
| title_fullStr | Motor and histological findings in a model of sci: comparison between posterior and lateral clips |
| title_full_unstemmed | Motor and histological findings in a model of sci: comparison between posterior and lateral clips |
| title_short | Motor and histological findings in a model of sci: comparison between posterior and lateral clips |
| title_sort | motor and histological findings in a model of sci comparison between posterior and lateral clips |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512014000400318&lng=en&tlng=en |
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