Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice
Inflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in patients with IBD, but the mechanistic link between IBD and anxiety remains elusive. Here, we sought to characterize...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical investigation
2023-06-01
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| Series: | JCI Insight |
| Subjects: | |
| Online Access: | https://doi.org/10.1172/jci.insight.161874 |
| _version_ | 1797634312671068160 |
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| author | Chin-Hao Chen Tsung-Chih Tsai Yi-Jen Wu Kuei-Sen Hsu |
| author_facet | Chin-Hao Chen Tsung-Chih Tsai Yi-Jen Wu Kuei-Sen Hsu |
| author_sort | Chin-Hao Chen |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in patients with IBD, but the mechanistic link between IBD and anxiety remains elusive. Here, we sought to characterize gut-to-brain signaling and brain circuitry responsible for the pathological expression of anxiety-like behaviors in male dextran sulfate sodium–induced (DSS-induced) experimental colitis mice. We found that DSS-treated mice displayed increased anxiety-like behaviors, which were prevented by bilateral GI vagal afferent ablation. The locus coeruleus (LC) is a relay center connecting the nucleus tractus solitarius to the basolateral amygdala (BLA) in controlling anxiety-like behaviors. Chemogenetic silencing of noradrenergic LC projections to the BLA reduced anxiety-like behaviors in DSS-treated mice. This work expands our understanding of the neural mechanisms by which IBD leads to comorbid anxiety and emphasizes a critical role of gastric vagal afferent signaling in gut-to-brain regulation of emotional states. |
| first_indexed | 2024-03-11T12:05:52Z |
| format | Article |
| id | doaj.art-a2e374c3fcab45329d35e2ac37088f76 |
| institution | Directory Open Access Journal |
| issn | 2379-3708 |
| language | English |
| last_indexed | 2024-03-11T12:05:52Z |
| publishDate | 2023-06-01 |
| publisher | American Society for Clinical investigation |
| record_format | Article |
| series | JCI Insight |
| spelling | doaj.art-a2e374c3fcab45329d35e2ac37088f762023-11-07T16:25:46ZengAmerican Society for Clinical investigationJCI Insight2379-37082023-06-01812Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis miceChin-Hao ChenTsung-Chih TsaiYi-Jen WuKuei-Sen HsuInflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in patients with IBD, but the mechanistic link between IBD and anxiety remains elusive. Here, we sought to characterize gut-to-brain signaling and brain circuitry responsible for the pathological expression of anxiety-like behaviors in male dextran sulfate sodium–induced (DSS-induced) experimental colitis mice. We found that DSS-treated mice displayed increased anxiety-like behaviors, which were prevented by bilateral GI vagal afferent ablation. The locus coeruleus (LC) is a relay center connecting the nucleus tractus solitarius to the basolateral amygdala (BLA) in controlling anxiety-like behaviors. Chemogenetic silencing of noradrenergic LC projections to the BLA reduced anxiety-like behaviors in DSS-treated mice. This work expands our understanding of the neural mechanisms by which IBD leads to comorbid anxiety and emphasizes a critical role of gastric vagal afferent signaling in gut-to-brain regulation of emotional states.https://doi.org/10.1172/jci.insight.161874Neuroscience |
| spellingShingle | Chin-Hao Chen Tsung-Chih Tsai Yi-Jen Wu Kuei-Sen Hsu Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice JCI Insight Neuroscience |
| title | Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice |
| title_full | Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice |
| title_fullStr | Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice |
| title_full_unstemmed | Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice |
| title_short | Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in experimental colitis mice |
| title_sort | gastric vagal afferent signaling to the basolateral amygdala mediates anxiety like behaviors in experimental colitis mice |
| topic | Neuroscience |
| url | https://doi.org/10.1172/jci.insight.161874 |
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