Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy
The individual and combined associations of polycyclic aromatic hydrocarbons (PAHs) metabolites on liver function during pregnancy are still lacking. We aimed to explore the connection between urinary PAH metabolites and liver function in early pregnant women in southwest China based on the Zunyi bi...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/10/863 |
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| author | Mi Dai Lei Luo Caiyan Xie Zhongbao Chen Mingzhe Zhang Yan Xie Xuejun Shang Xubo Shen Kunming Tian Yuanzhong Zhou |
| author_facet | Mi Dai Lei Luo Caiyan Xie Zhongbao Chen Mingzhe Zhang Yan Xie Xuejun Shang Xubo Shen Kunming Tian Yuanzhong Zhou |
| author_sort | Mi Dai |
| collection | DOAJ |
| description | The individual and combined associations of polycyclic aromatic hydrocarbons (PAHs) metabolites on liver function during pregnancy are still lacking. We aimed to explore the connection between urinary PAH metabolites and liver function in early pregnant women in southwest China based on the Zunyi birth cohort. Ten urinary PAH metabolites and five liver function parameters during early pregnancy were measured. The associations of single PAHs with parameters of liver function were assessed using multiple linear regression. A Bayesian kernel machine regression (BKMR) model was used to evaluate the joint associations of the PAH mixture with outcomes. We found that each 1% increment of urinary 2-hydroxyphenanthrene (2-OH-PHE) was associated with 3.36% (95% CI: 0.40%, 6.40%) higher alanine aminotransferase (ALT) and 2.22% (95% CI: 0.80%, 3.67%) higher aspartate aminotransferase (AST). Each 1% increment in 1-hydroxy-phenanthrene (1-OH-PHE) was significantly associated with 7.04% (95% CI: 1.61%, 12.75%) increased total bile acid (TBA). Additionally, there was a significant positive linear trend between 2-OH-PHE and AST and 1-OH-PHE and TBA. BKMR also showed a significant positive association of PAH mixture with AST. Our results indicate that PAH metabolites were associated with increased parameters of liver function among early pregnant women. Early pregnant women should pay more attention to the adverse relationships between PAHs and liver function parameters to prevent environment-related adverse perinatal outcomes. |
| first_indexed | 2024-03-10T20:51:09Z |
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| id | doaj.art-a2e41b568e7f47a2a7e660a560977ed6 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T20:51:09Z |
| publishDate | 2023-10-01 |
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| series | Toxics |
| spelling | doaj.art-a2e41b568e7f47a2a7e660a560977ed62023-11-19T18:22:07ZengMDPI AGToxics2305-63042023-10-01111086310.3390/toxics11100863Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early PregnancyMi Dai0Lei Luo1Caiyan Xie2Zhongbao Chen3Mingzhe Zhang4Yan Xie5Xuejun Shang6Xubo Shen7Kunming Tian8Yuanzhong Zhou9The Third Affiliated Hospital, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaRenhuai Center for Disease Control and Prevention, Zunyi 563000, ChinaReproductive Center, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Andrology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing 210002, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaThe individual and combined associations of polycyclic aromatic hydrocarbons (PAHs) metabolites on liver function during pregnancy are still lacking. We aimed to explore the connection between urinary PAH metabolites and liver function in early pregnant women in southwest China based on the Zunyi birth cohort. Ten urinary PAH metabolites and five liver function parameters during early pregnancy were measured. The associations of single PAHs with parameters of liver function were assessed using multiple linear regression. A Bayesian kernel machine regression (BKMR) model was used to evaluate the joint associations of the PAH mixture with outcomes. We found that each 1% increment of urinary 2-hydroxyphenanthrene (2-OH-PHE) was associated with 3.36% (95% CI: 0.40%, 6.40%) higher alanine aminotransferase (ALT) and 2.22% (95% CI: 0.80%, 3.67%) higher aspartate aminotransferase (AST). Each 1% increment in 1-hydroxy-phenanthrene (1-OH-PHE) was significantly associated with 7.04% (95% CI: 1.61%, 12.75%) increased total bile acid (TBA). Additionally, there was a significant positive linear trend between 2-OH-PHE and AST and 1-OH-PHE and TBA. BKMR also showed a significant positive association of PAH mixture with AST. Our results indicate that PAH metabolites were associated with increased parameters of liver function among early pregnant women. Early pregnant women should pay more attention to the adverse relationships between PAHs and liver function parameters to prevent environment-related adverse perinatal outcomes.https://www.mdpi.com/2305-6304/11/10/863polycyclic aromatic hydrocarbonsliver functionBKMRpregnant womenZunyi birth cohort |
| spellingShingle | Mi Dai Lei Luo Caiyan Xie Zhongbao Chen Mingzhe Zhang Yan Xie Xuejun Shang Xubo Shen Kunming Tian Yuanzhong Zhou Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy Toxics polycyclic aromatic hydrocarbons liver function BKMR pregnant women Zunyi birth cohort |
| title | Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy |
| title_full | Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy |
| title_fullStr | Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy |
| title_full_unstemmed | Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy |
| title_short | Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy |
| title_sort | single and joint associations of polycyclic aromatic hydrocarbon exposure with liver function during early pregnancy |
| topic | polycyclic aromatic hydrocarbons liver function BKMR pregnant women Zunyi birth cohort |
| url | https://www.mdpi.com/2305-6304/11/10/863 |
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