Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies
Abstract Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated immune cells that are engineered and administered to eliminate cancer cells. In this context, CAR T-cells have sh...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-03163-w |
| _version_ | 1811264910050459648 |
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| author | Ali Keshavarz Ali Salehi Setareh Khosravi Yasaman Shariati Navid Nasrabadi Mohammad Saeed Kahrizi Sairan Maghsoodi Amirhossein Mardi Ramyar Azizi Samira Jamali Farnoush Fotovat |
| author_facet | Ali Keshavarz Ali Salehi Setareh Khosravi Yasaman Shariati Navid Nasrabadi Mohammad Saeed Kahrizi Sairan Maghsoodi Amirhossein Mardi Ramyar Azizi Samira Jamali Farnoush Fotovat |
| author_sort | Ali Keshavarz |
| collection | DOAJ |
| description | Abstract Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated immune cells that are engineered and administered to eliminate cancer cells. In this context, CAR T-cells have shown significant promise in the treatment of hematological malignancies. However, many obstacles limit the efficacy of CAR T-cell therapy in both solid tumors and hematological malignancies. Consequently, CAR-NK and CAR-M cell therapies have recently emerged as novel therapeutic options for addressing the challenges associated with CAR T-cell therapies. Currently, many CAR immune cell trials are underway in various human malignancies around the world to improve antitumor activity and reduce the toxicity of CAR immune cell therapy. This review will describe the comprehensive literature of recent findings on CAR immune cell therapy in a wide range of human malignancies, as well as the challenges that have emerged in recent years. |
| first_indexed | 2024-04-12T20:13:05Z |
| format | Article |
| id | doaj.art-a2e59210727b43c29f6e2a851bf372c5 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-12T20:13:05Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-a2e59210727b43c29f6e2a851bf372c52022-12-22T03:18:12ZengBMCStem Cell Research & Therapy1757-65122022-09-0113112210.1186/s13287-022-03163-wRecent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignanciesAli Keshavarz0Ali Salehi1Setareh Khosravi2Yasaman Shariati3Navid Nasrabadi4Mohammad Saeed Kahrizi5Sairan Maghsoodi6Amirhossein Mardi7Ramyar Azizi8Samira Jamali9Farnoush Fotovat10Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical SciencesDepartment of Oral and Maxillofacial Radiology, School of Dentistry, Islamic Azad University,, Isfahan (Khorasgan) BranchDepartment of Orthodontics, School of Dentistry, Alborz University of Medical SciencesDepartment of General Surgery, School of Medicine, Arak University of Medical SciencesDepartment of Endodontics, School of Dentistry, Birjand University of Medical SciencesAlborz University of Medical SciencesDepartment of Paramedical, Kurdistan University of Medical SciencesDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Immunology, Faculty of Medicine, Tabriz University of Medical SciencesDepartment of Endodontics, College of Stomatology, Stomatological Hospital, Xi’an Jiaotong UniversityDepartment of Prosthodontics, School of Dentistry, Hamadan University of Medical SciencesAbstract Advancements in adoptive cell therapy over the last four decades have revealed various new therapeutic strategies, such as chimeric antigen receptors (CARs), which are dedicated immune cells that are engineered and administered to eliminate cancer cells. In this context, CAR T-cells have shown significant promise in the treatment of hematological malignancies. However, many obstacles limit the efficacy of CAR T-cell therapy in both solid tumors and hematological malignancies. Consequently, CAR-NK and CAR-M cell therapies have recently emerged as novel therapeutic options for addressing the challenges associated with CAR T-cell therapies. Currently, many CAR immune cell trials are underway in various human malignancies around the world to improve antitumor activity and reduce the toxicity of CAR immune cell therapy. This review will describe the comprehensive literature of recent findings on CAR immune cell therapy in a wide range of human malignancies, as well as the challenges that have emerged in recent years.https://doi.org/10.1186/s13287-022-03163-wImmunotherapyChimeric antigen receptorsCAR T-cellCAR-NK cellCAR-M solid tumorsHematological malignancies |
| spellingShingle | Ali Keshavarz Ali Salehi Setareh Khosravi Yasaman Shariati Navid Nasrabadi Mohammad Saeed Kahrizi Sairan Maghsoodi Amirhossein Mardi Ramyar Azizi Samira Jamali Farnoush Fotovat Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies Stem Cell Research & Therapy Immunotherapy Chimeric antigen receptors CAR T-cell CAR-NK cell CAR-M solid tumors Hematological malignancies |
| title | Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies |
| title_full | Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies |
| title_fullStr | Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies |
| title_full_unstemmed | Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies |
| title_short | Recent findings on chimeric antigen receptor (CAR)-engineered immune cell therapy in solid tumors and hematological malignancies |
| title_sort | recent findings on chimeric antigen receptor car engineered immune cell therapy in solid tumors and hematological malignancies |
| topic | Immunotherapy Chimeric antigen receptors CAR T-cell CAR-NK cell CAR-M solid tumors Hematological malignancies |
| url | https://doi.org/10.1186/s13287-022-03163-w |
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