Effects of glucocorticoids in depression: Role of astrocytes
Astrocytes or astroglia are heterogeneous cells, similar to neurons, that have different properties in different brain regions. The implications of steroid hormones on glial cells and stress-related pathologies have been studied previously. Glucocorticoids (GCs) that are released in response to stre...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2018-08-01
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| Series: | AIMS Neuroscience |
| Subjects: | |
| Online Access: | http://www.aimspress.com/article/10.3934/Neuroscience.2018.3.200/fulltext.html |
| _version_ | 1811288622535540736 |
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| author | Pranav Chintamani Joshi Sugato Benerjee |
| author_facet | Pranav Chintamani Joshi Sugato Benerjee |
| author_sort | Pranav Chintamani Joshi |
| collection | DOAJ |
| description | Astrocytes or astroglia are heterogeneous cells, similar to neurons, that have different properties in different brain regions. The implications of steroid hormones on glial cells and stress-related pathologies have been studied previously. Glucocorticoids (GCs) that are released in response to stress have been shown to be deleterious to neurons in various brain regions. Further, in the light of the effect of GCs on astrocytes, several reports have shown the crucial role of glia. Still, much remains to be done to understand the stress-astrocytes-glucocorticoid interactions associated with the pathological consequences of various CNS disorders. This review is an attempt to summarize the effects of GCs and stress on astrocytes and its implications in depression. |
| first_indexed | 2024-04-13T03:40:32Z |
| format | Article |
| id | doaj.art-a2e5b79b3c0b4a5981d7c903745a5240 |
| institution | Directory Open Access Journal |
| issn | 2373-8006 2373-7972 |
| language | English |
| last_indexed | 2024-04-13T03:40:32Z |
| publishDate | 2018-08-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj.art-a2e5b79b3c0b4a5981d7c903745a52402022-12-22T03:04:10ZengAIMS PressAIMS Neuroscience2373-80062373-79722018-08-015320021010.3934/Neuroscience.2018.3.200Effects of glucocorticoids in depression: Role of astrocytesPranav Chintamani Joshi0Sugato Benerjee1Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, IndiaDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, IndiaAstrocytes or astroglia are heterogeneous cells, similar to neurons, that have different properties in different brain regions. The implications of steroid hormones on glial cells and stress-related pathologies have been studied previously. Glucocorticoids (GCs) that are released in response to stress have been shown to be deleterious to neurons in various brain regions. Further, in the light of the effect of GCs on astrocytes, several reports have shown the crucial role of glia. Still, much remains to be done to understand the stress-astrocytes-glucocorticoid interactions associated with the pathological consequences of various CNS disorders. This review is an attempt to summarize the effects of GCs and stress on astrocytes and its implications in depression.http://www.aimspress.com/article/10.3934/Neuroscience.2018.3.200/fulltext.htmlanxiety| astrocytes| depression| glucocorticoids| stress |
| spellingShingle | Pranav Chintamani Joshi Sugato Benerjee Effects of glucocorticoids in depression: Role of astrocytes AIMS Neuroscience anxiety| astrocytes| depression| glucocorticoids| stress |
| title | Effects of glucocorticoids in depression: Role of astrocytes |
| title_full | Effects of glucocorticoids in depression: Role of astrocytes |
| title_fullStr | Effects of glucocorticoids in depression: Role of astrocytes |
| title_full_unstemmed | Effects of glucocorticoids in depression: Role of astrocytes |
| title_short | Effects of glucocorticoids in depression: Role of astrocytes |
| title_sort | effects of glucocorticoids in depression role of astrocytes |
| topic | anxiety| astrocytes| depression| glucocorticoids| stress |
| url | http://www.aimspress.com/article/10.3934/Neuroscience.2018.3.200/fulltext.html |
| work_keys_str_mv | AT pranavchintamanijoshi effectsofglucocorticoidsindepressionroleofastrocytes AT sugatobenerjee effectsofglucocorticoidsindepressionroleofastrocytes |