Synthesis, Conformational Analysis and Evaluation of the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines as Potential α-Glucosidase and/or α-Amylase Inhibitors

Synthesis, Conformational Analysis and Evaluation of the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines as Potential α-Glucosidase and/or α-Amylase Inhibitors

The ambident electrophilic character of the 5-bromo-2-hydroxychalcones and the binucleophilic nature of 2-aminothiophenol were exploited to construct the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines. The structures and conformation of these 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thia...

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Bibliographic Details
Main Authors: Jackson K. Nkoana, Marole M. Maluleka, Malose J. Mphahlele, Richard M. Mampa, Yee Siew Choong
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
2,3-dihydrobenzo[<i>b</i>][1,5]thiazepines
X-ray structure
DFT
α-glucosidase
α-amylase
computational studies
Online Access:https://www.mdpi.com/1420-3049/27/20/6935

Internet

https://www.mdpi.com/1420-3049/27/20/6935

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