The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes

The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes

Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ starting with Asp1 (Aβ1−x). A candidate protease for the generatio...

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Bibliographic Details
Main Authors: Timo Jan Oberstein, Janine Utz, Philipp Spitzer, Hans Wolfgang Klafki, Jens Wiltfang, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer's disease
amyloid beta
cathepsin B
N-terminus
astrocytes
lysosomal
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.615740/full

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