Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss
Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) with comprehensive chromosome screening increases live birth rate (LBR) in normal karyotype couples with recurrent pregnancy loss (RPL). Methods: A retrospective cohort follow-up study of 506 couples with RPL was c...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2019-01-01
|
| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=205;epage=212;aulast=Lei |
| _version_ | 1818237787964440576 |
|---|---|
| author | Cai-Xia Lei Jiang-Feng Ye Yi-Lun Sui Yue-Ping Zhang Xiao-Xi Sun |
| author_facet | Cai-Xia Lei Jiang-Feng Ye Yi-Lun Sui Yue-Ping Zhang Xiao-Xi Sun |
| author_sort | Cai-Xia Lei |
| collection | DOAJ |
| description | Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) with comprehensive chromosome screening increases live birth rate (LBR) in normal karyotype couples with recurrent pregnancy loss (RPL).
Methods: A retrospective cohort follow-up study of 506 couples with RPL was conducted between April 2014 and March 2017. Couples were allocated to two groups according to their decision to choose PGT-A or not. The primary outcome was LBR per start/transfer cycle; secondary outcomes were ongoing pregnancy rate and miscarriage rate. Statistical analyses were conducted using univariate and multivariate logistic regression models adjusted for maternal age.
Results: LBR per start (26.6% vs. 15.4%, relative risk [RR]: 2.66, 95% confidence interval [CI] [1.69–4.20], P < 0.0001; adjusted RR [aRR]: 2.40, 95% CI [1.49–3.86], P = 0.0004) and per transfer (44.9% vs. 25.1%, RR: 3.00, 95% CI [1.96–4.60], P < 0.0001; aRR: 2.64, 95% CI [1.68–4.14], P < 0.0001) was significantly higher in the PGT-A group than in the non-PGT-A group. The miscarriage rate was significantly lower in the PGT-A group compared to the non-PGT-A group (15.7% vs. 34.6%, RR: 0.27, 95% CI [0.13–0.57], P = 0.00005; aRR: 0.26, 95% CI [0.12–0.57], P = 0.0007).
Conclusions: LBR per start cycle following PGT-A is significantly higher, and risk of miscarriage is significantly lower among infertile couples with RPL, irrespective of maternal age. PGT-A should be recommended to infertile couples with RPL. |
| first_indexed | 2024-12-12T12:31:19Z |
| format | Article |
| id | doaj.art-a2ebad78292b4b9f8c7ebdff953fb7f5 |
| institution | Directory Open Access Journal |
| issn | 2096-2924 2589-8728 |
| language | English |
| last_indexed | 2024-12-12T12:31:19Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-a2ebad78292b4b9f8c7ebdff953fb7f52022-12-22T00:24:25ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242589-87282019-01-013420521210.4103/2096-2924.274544Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy lossCai-Xia LeiJiang-Feng YeYi-Lun SuiYue-Ping ZhangXiao-Xi SunObjective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) with comprehensive chromosome screening increases live birth rate (LBR) in normal karyotype couples with recurrent pregnancy loss (RPL). Methods: A retrospective cohort follow-up study of 506 couples with RPL was conducted between April 2014 and March 2017. Couples were allocated to two groups according to their decision to choose PGT-A or not. The primary outcome was LBR per start/transfer cycle; secondary outcomes were ongoing pregnancy rate and miscarriage rate. Statistical analyses were conducted using univariate and multivariate logistic regression models adjusted for maternal age. Results: LBR per start (26.6% vs. 15.4%, relative risk [RR]: 2.66, 95% confidence interval [CI] [1.69–4.20], P < 0.0001; adjusted RR [aRR]: 2.40, 95% CI [1.49–3.86], P = 0.0004) and per transfer (44.9% vs. 25.1%, RR: 3.00, 95% CI [1.96–4.60], P < 0.0001; aRR: 2.64, 95% CI [1.68–4.14], P < 0.0001) was significantly higher in the PGT-A group than in the non-PGT-A group. The miscarriage rate was significantly lower in the PGT-A group compared to the non-PGT-A group (15.7% vs. 34.6%, RR: 0.27, 95% CI [0.13–0.57], P = 0.00005; aRR: 0.26, 95% CI [0.12–0.57], P = 0.0007). Conclusions: LBR per start cycle following PGT-A is significantly higher, and risk of miscarriage is significantly lower among infertile couples with RPL, irrespective of maternal age. PGT-A should be recommended to infertile couples with RPL.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=205;epage=212;aulast=Leicomprehensive chromosome screening; preimplantation genetic testing for aneuploidy; recurrent pregnancy loss |
| spellingShingle | Cai-Xia Lei Jiang-Feng Ye Yi-Lun Sui Yue-Ping Zhang Xiao-Xi Sun Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss Reproductive and Developmental Medicine comprehensive chromosome screening; preimplantation genetic testing for aneuploidy; recurrent pregnancy loss |
| title | Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss |
| title_full | Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss |
| title_fullStr | Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss |
| title_full_unstemmed | Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss |
| title_short | Retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype, secondary infertility patients with recurrent pregnancy loss |
| title_sort | retrospective cohort study of preimplantation genetic testing for aneuploidy with comprehensive chromosome screening versus nonpreimplantation genetic testing in normal karyotype secondary infertility patients with recurrent pregnancy loss |
| topic | comprehensive chromosome screening; preimplantation genetic testing for aneuploidy; recurrent pregnancy loss |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2019;volume=3;issue=4;spage=205;epage=212;aulast=Lei |
| work_keys_str_mv | AT caixialei retrospectivecohortstudyofpreimplantationgenetictestingforaneuploidywithcomprehensivechromosomescreeningversusnonpreimplantationgenetictestinginnormalkaryotypesecondaryinfertilitypatientswithrecurrentpregnancyloss AT jiangfengye retrospectivecohortstudyofpreimplantationgenetictestingforaneuploidywithcomprehensivechromosomescreeningversusnonpreimplantationgenetictestinginnormalkaryotypesecondaryinfertilitypatientswithrecurrentpregnancyloss AT yilunsui retrospectivecohortstudyofpreimplantationgenetictestingforaneuploidywithcomprehensivechromosomescreeningversusnonpreimplantationgenetictestinginnormalkaryotypesecondaryinfertilitypatientswithrecurrentpregnancyloss AT yuepingzhang retrospectivecohortstudyofpreimplantationgenetictestingforaneuploidywithcomprehensivechromosomescreeningversusnonpreimplantationgenetictestinginnormalkaryotypesecondaryinfertilitypatientswithrecurrentpregnancyloss AT xiaoxisun retrospectivecohortstudyofpreimplantationgenetictestingforaneuploidywithcomprehensivechromosomescreeningversusnonpreimplantationgenetictestinginnormalkaryotypesecondaryinfertilitypatientswithrecurrentpregnancyloss |