Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women
Abstract Background Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular specie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0785-6 |
| _version_ | 1818009753796739072 |
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| author | Noriaki Kawanishi Yuki Kato Kyosuke Yokozeki Shuji Sawada Ryota Sakurai Yoshinori Fujiwara Shoji Shinkai Nobuhito Goda Katsuhiko Suzuki |
| author_facet | Noriaki Kawanishi Yuki Kato Kyosuke Yokozeki Shuji Sawada Ryota Sakurai Yoshinori Fujiwara Shoji Shinkai Nobuhito Goda Katsuhiko Suzuki |
| author_sort | Noriaki Kawanishi |
| collection | DOAJ |
| description | Abstract Background Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular species induced by aging are still unknown. We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis. Methods Serum samples were collected from ten elderly men (71.7 ± 0.5 years old) and women (70.2 ± 1.0 years old), ten young men (23.9 ± 0.4 years old), and women (23.9 ± 0.7 years old). Serum levels of lipid molecular species were determined by liquid chromatography mass spectrometry-based lipidomics analysis. Results Our mass spectrometry analysis revealed increases in the levels of multiple triacylglycerol molecular species in the serum of elderly men and women. Moreover, serum levels of total ester-linked phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were increased by aging. In contrast, serum levels of specific ether-linked PC and PE molecular species were lower in elderly individuals than in young individuals. Conclusions Our finding indicates that specific lipid molecular species, such as ether- and ester- linked phospholipids, may be selectively altered by aging. |
| first_indexed | 2024-04-14T05:46:54Z |
| format | Article |
| id | doaj.art-a2eca8e66a58414b950d06982b5a92cb |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T05:46:54Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-a2eca8e66a58414b950d06982b5a92cb2022-12-22T02:09:16ZengBMCLipids in Health and Disease1476-511X2018-06-011711810.1186/s12944-018-0785-6Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and womenNoriaki Kawanishi0Yuki Kato1Kyosuke Yokozeki2Shuji Sawada3Ryota Sakurai4Yoshinori Fujiwara5Shoji Shinkai6Nobuhito Goda7Katsuhiko Suzuki8Institute for Nanoscience & Nanotechnology, Waseda UniversityDepartment of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda UniversityDepartment of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda UniversityInstitute for Nanoscience & Nanotechnology, Waseda UniversityResearch Team for Social Participation and Community Health, Tokyo Metropolitan Institute of GerontologyResearch Team for Social Participation and Community Health, Tokyo Metropolitan Institute of GerontologyResearch Team for Social Participation and Community Health, Tokyo Metropolitan Institute of GerontologyDepartment of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda UniversityFaculty of Sports Science, Waseda UniversityAbstract Background Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular species induced by aging are still unknown. We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis. Methods Serum samples were collected from ten elderly men (71.7 ± 0.5 years old) and women (70.2 ± 1.0 years old), ten young men (23.9 ± 0.4 years old), and women (23.9 ± 0.7 years old). Serum levels of lipid molecular species were determined by liquid chromatography mass spectrometry-based lipidomics analysis. Results Our mass spectrometry analysis revealed increases in the levels of multiple triacylglycerol molecular species in the serum of elderly men and women. Moreover, serum levels of total ester-linked phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were increased by aging. In contrast, serum levels of specific ether-linked PC and PE molecular species were lower in elderly individuals than in young individuals. Conclusions Our finding indicates that specific lipid molecular species, such as ether- and ester- linked phospholipids, may be selectively altered by aging.http://link.springer.com/article/10.1186/s12944-018-0785-6AgingLipidomicsLipidMolecular species |
| spellingShingle | Noriaki Kawanishi Yuki Kato Kyosuke Yokozeki Shuji Sawada Ryota Sakurai Yoshinori Fujiwara Shoji Shinkai Nobuhito Goda Katsuhiko Suzuki Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women Lipids in Health and Disease Aging Lipidomics Lipid Molecular species |
| title | Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women |
| title_full | Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women |
| title_fullStr | Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women |
| title_full_unstemmed | Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women |
| title_short | Effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in Japanese men and women |
| title_sort | effects of aging on serum levels of lipid molecular species as determined by lipidomics analysis in japanese men and women |
| topic | Aging Lipidomics Lipid Molecular species |
| url | http://link.springer.com/article/10.1186/s12944-018-0785-6 |
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