Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives
New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloro...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2015-09-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2099 |
| _version_ | 1818034835724173312 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | New series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial species |
| first_indexed | 2024-12-10T06:45:29Z |
| format | Article |
| id | doaj.art-a2ed5f606e86476b8187cf2fc136274b |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-10T06:45:29Z |
| publishDate | 2015-09-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-a2ed5f606e86476b8187cf2fc136274b2022-12-22T01:58:40ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862015-09-0112310.21123/bsj.12.3.546-554Synthesis, Characterization and Antibacterial Activity of Cefalexin DervativesBaghdad Science JournalNew series of Schiff bases 2(a-j) and corresponding beta-lactam derivatives 3(a-j) were synthesized from cefalexin (1) as starting material. The compound (1) was reacted with different aldehydes and ketones to give Schiff bases derivatives 2(a-j). The synthesized Schiff bases were cyclized by chloroacetyl chloride in the presence of triethylamine to form beta-lactam derivatives 3(a-j). The compounds were characterized by deremination melting point, FT-IR and 1H NMR. The beta-lactam derivatives were screened in vitro antibacterial against some bacterial specieshttp://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2099cefalexin, Schiff base, Beta-lactam, Antibacterial activity |
| spellingShingle | Baghdad Science Journal Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives Baghdad Science Journal cefalexin, Schiff base, Beta-lactam, Antibacterial activity |
| title | Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives |
| title_full | Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives |
| title_fullStr | Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives |
| title_full_unstemmed | Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives |
| title_short | Synthesis, Characterization and Antibacterial Activity of Cefalexin Dervatives |
| title_sort | synthesis characterization and antibacterial activity of cefalexin dervatives |
| topic | cefalexin, Schiff base, Beta-lactam, Antibacterial activity |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2099 |
| work_keys_str_mv | AT baghdadsciencejournal synthesischaracterizationandantibacterialactivityofcefalexindervatives |