Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery
Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conduc...
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MDPI AG
2023-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/7/863 |
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| author | Gianna Dipalma Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Fabio Viapiano Anna Netti Assunta Patano Ciro Gargiulo Isacco Alessio Danilo Inchingolo Francesco Inchingolo |
| author_facet | Gianna Dipalma Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Fabio Viapiano Anna Netti Assunta Patano Ciro Gargiulo Isacco Alessio Danilo Inchingolo Francesco Inchingolo |
| author_sort | Gianna Dipalma |
| collection | DOAJ |
| description | Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conducted at the Dental Unit of the University of Bari, Italy. Patients with MRONJ were treated and followed up for 60 months. The treatment approach involved piezosurgery and concentrated growth factor (CGF). Six clinical cases from this group are described in detail. Results: None of the patients showed recurrence of necrotic MRONJ lesions during the follow-up period. The surgical interventions, including bone resections and the application of CGF, resulted in successful mucosal healing and the prevention of disease progression. Conclusions: This study highlights the complexity of managing MRONJ and the importance of a multidisciplinary approach. Conservative treatment options and minimally invasive surgery have shown efficacy in controlling symptoms and improving patients’ quality of life. However, the optimal treatment approach remains a challenge, and further studies are needed to evaluate alternative therapies and resective surgery. A comprehensive preoperative evaluation and collaboration among dental, endocrinology, and oncology specialists are crucial for personalized and multidisciplinary management. Ongoing research efforts are necessary to explore new therapeutic modalities and improve our understanding of MRONJ management, providing better support to patients dealing with this complex condition. |
| first_indexed | 2024-03-11T01:17:51Z |
| format | Article |
| id | doaj.art-a2ed7dfad3bc42e48bc0f182653bcdec |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T01:17:51Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-a2ed7dfad3bc42e48bc0f182653bcdec2023-11-18T18:22:24ZengMDPI AGBioengineering2306-53542023-07-0110786310.3390/bioengineering10070863Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and PiezosurgeryGianna Dipalma0Angelo Michele Inchingolo1Giuseppina Malcangi2Irene Ferrara3Fabio Viapiano4Anna Netti5Assunta Patano6Ciro Gargiulo Isacco7Alessio Danilo Inchingolo8Francesco Inchingolo9Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyAims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conducted at the Dental Unit of the University of Bari, Italy. Patients with MRONJ were treated and followed up for 60 months. The treatment approach involved piezosurgery and concentrated growth factor (CGF). Six clinical cases from this group are described in detail. Results: None of the patients showed recurrence of necrotic MRONJ lesions during the follow-up period. The surgical interventions, including bone resections and the application of CGF, resulted in successful mucosal healing and the prevention of disease progression. Conclusions: This study highlights the complexity of managing MRONJ and the importance of a multidisciplinary approach. Conservative treatment options and minimally invasive surgery have shown efficacy in controlling symptoms and improving patients’ quality of life. However, the optimal treatment approach remains a challenge, and further studies are needed to evaluate alternative therapies and resective surgery. A comprehensive preoperative evaluation and collaboration among dental, endocrinology, and oncology specialists are crucial for personalized and multidisciplinary management. Ongoing research efforts are necessary to explore new therapeutic modalities and improve our understanding of MRONJ management, providing better support to patients dealing with this complex condition.https://www.mdpi.com/2306-5354/10/7/863MRONJosteonecrosisdenosumabDRONJconcentrated growth factorplatelet-rich plasma |
| spellingShingle | Gianna Dipalma Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Fabio Viapiano Anna Netti Assunta Patano Ciro Gargiulo Isacco Alessio Danilo Inchingolo Francesco Inchingolo Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery Bioengineering MRONJ osteonecrosis denosumab DRONJ concentrated growth factor platelet-rich plasma |
| title | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
| title_full | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
| title_fullStr | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
| title_full_unstemmed | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
| title_short | Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery |
| title_sort | sixty month follow up of clinical mronj cases treated with cgf and piezosurgery |
| topic | MRONJ osteonecrosis denosumab DRONJ concentrated growth factor platelet-rich plasma |
| url | https://www.mdpi.com/2306-5354/10/7/863 |
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