Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death

Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death

<p>Abstract</p> <p>With cAMP signaling having a profound inhibitory effect on DNA damage-induced apoptosis in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells, understanding how this signaling pathway affects the survival capacity of the cell has important implications...

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Bibliographic Details
Main Authors: Blomhoff Heidi K, Carlsen Harald, Naderi Elin H, Kloster Martine M, Naderi Soheil
Format: Article
Language:English
Published: BMC 2011-04-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/10/1/45

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